node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PAE0764 | PAE2365 | PAE0764 | PAE2365 | Phosphomannomutase (pmm); Cell envelope; Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides; Belongs to the phosphohexose mutase family. | Nucleoside-triphosphatase (NTPase); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.516 |
PAE0764 | PAE2937 | PAE0764 | PAE2937 | Phosphomannomutase (pmm); Cell envelope; Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides; Belongs to the phosphohexose mutase family. | Dihydropteroate synthase; Biosynthesis of cofactors, prosthetic groups, and carriers; Folic acid. | 0.649 |
PAE0764 | folD | PAE0764 | PAE0220 | Phosphomannomutase (pmm); Cell envelope; Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides; Belongs to the phosphohexose mutase family. | Methylenetetrahydrofolate dehydrogenase (folD); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.462 |
PAE1703 | PAE2328 | PAE1703 | PAE2328 | Hypothetical protein. | Conserved hypothetical protein. | 0.903 |
PAE1703 | PAE2937 | PAE1703 | PAE2937 | Hypothetical protein. | Dihydropteroate synthase; Biosynthesis of cofactors, prosthetic groups, and carriers; Folic acid. | 0.920 |
PAE2328 | PAE1703 | PAE2328 | PAE1703 | Conserved hypothetical protein. | Hypothetical protein. | 0.903 |
PAE2328 | PAE2937 | PAE2328 | PAE2937 | Conserved hypothetical protein. | Dihydropteroate synthase; Biosynthesis of cofactors, prosthetic groups, and carriers; Folic acid. | 0.939 |
PAE2365 | PAE0764 | PAE2365 | PAE0764 | Nucleoside-triphosphatase (NTPase); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Phosphomannomutase (pmm); Cell envelope; Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides; Belongs to the phosphohexose mutase family. | 0.516 |
PAE2365 | PAE2937 | PAE2365 | PAE2937 | Nucleoside-triphosphatase (NTPase); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Dihydropteroate synthase; Biosynthesis of cofactors, prosthetic groups, and carriers; Folic acid. | 0.753 |
PAE2365 | PAE2985 | PAE2365 | PAE2985 | Nucleoside-triphosphatase (NTPase); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Riboflavin specific deaminase, putative; Biosynthesis of cofactors, prosthetic groups, and carriers; Riboflavin, FMN, and FAD. | 0.429 |
PAE2365 | folE | PAE2365 | PAE1588 | Nucleoside-triphosphatase (NTPase); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GTP cyclohydrolase I; Biosynthesis of cofactors, prosthetic groups, and carriers; Folic acid. | 0.789 |
PAE2459 | PAE2937 | PAE2459 | PAE2937 | Anthranilate synthase component II; Amino acid biosynthesis; Aromatic amino acid family. | Dihydropteroate synthase; Biosynthesis of cofactors, prosthetic groups, and carriers; Folic acid. | 0.779 |
PAE2459 | folE | PAE2459 | PAE1588 | Anthranilate synthase component II; Amino acid biosynthesis; Aromatic amino acid family. | GTP cyclohydrolase I; Biosynthesis of cofactors, prosthetic groups, and carriers; Folic acid. | 0.488 |
PAE2937 | PAE0764 | PAE2937 | PAE0764 | Dihydropteroate synthase; Biosynthesis of cofactors, prosthetic groups, and carriers; Folic acid. | Phosphomannomutase (pmm); Cell envelope; Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides; Belongs to the phosphohexose mutase family. | 0.649 |
PAE2937 | PAE1703 | PAE2937 | PAE1703 | Dihydropteroate synthase; Biosynthesis of cofactors, prosthetic groups, and carriers; Folic acid. | Hypothetical protein. | 0.920 |
PAE2937 | PAE2328 | PAE2937 | PAE2328 | Dihydropteroate synthase; Biosynthesis of cofactors, prosthetic groups, and carriers; Folic acid. | Conserved hypothetical protein. | 0.939 |
PAE2937 | PAE2365 | PAE2937 | PAE2365 | Dihydropteroate synthase; Biosynthesis of cofactors, prosthetic groups, and carriers; Folic acid. | Nucleoside-triphosphatase (NTPase); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.753 |
PAE2937 | PAE2459 | PAE2937 | PAE2459 | Dihydropteroate synthase; Biosynthesis of cofactors, prosthetic groups, and carriers; Folic acid. | Anthranilate synthase component II; Amino acid biosynthesis; Aromatic amino acid family. | 0.779 |
PAE2937 | PAE2939 | PAE2937 | PAE2939 | Dihydropteroate synthase; Biosynthesis of cofactors, prosthetic groups, and carriers; Folic acid. | Conserved hypothetical protein. | 0.647 |
PAE2937 | PAE2985 | PAE2937 | PAE2985 | Dihydropteroate synthase; Biosynthesis of cofactors, prosthetic groups, and carriers; Folic acid. | Riboflavin specific deaminase, putative; Biosynthesis of cofactors, prosthetic groups, and carriers; Riboflavin, FMN, and FAD. | 0.672 |