Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE29773-hydroxyisobutyrate dehydrogenase, putative; Unclassified. (270 aa)    
Predicted Functional Partners:
PAE2972
Conserved hypothetical protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily.
       0.795
PAE2973
asparaginyl-tRNA synthetase; Protein synthesis; tRNA aminoacylation.
       0.795
PAE2975
Conserved hypothetical protein.
       0.795
PAE2978
Sua5 family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.
       0.574
PAE2979
Methyltransferase; Unclassified.
       0.574
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P).
       0.514
PAE1650
enoyl-CoA hydratase, probable; Fatty acid and phospholipid metabolism; Degradation.
  
  
 0.443
PAE2479
enoyl-CoA hydratase; Fatty acid and phospholipid metabolism; Degradation.
  
  
 0.443
PAE2480
Aldehyde dehydrogenase; Unclassified.
  
  
 0.409
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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