STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (284 aa)    
Predicted Functional Partners:
PAE2646
Pyruvate dehydrogenase E1 beta subunit; Energy metabolism; Glycolysis/gluconeogenesis.
  
 0.997
PAE2648
Pyruvate dehydrogenase E2 (dihydrolipoamide acetyltransferase); Energy metabolism; Glycolysis/gluconeogenesis.
 
 0.976
PAE1027
Ribose 5-phosphate isomerase; Energy metabolism; Pentose phosphate pathway.
  
 
 0.948
PAE0835
Sugar kinase, possible phosphofructokinase; Energy metabolism; Glycolysis/gluconeogenesis; Belongs to the carbohydrate kinase PfkB family.
  
 0.946
PAE0218
Amidophosphoribosyltransferase (purF); Purines, pyrimidines, nucleosides, and nucleotides; Purine ribonucleotide biosynthesis.
  
 0.939
PAE0226
Amidophosphoribosyltransferase (purF); Purines, pyrimidines, nucleosides, and nucleotides; Purine ribonucleotide biosynthesis; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 0.939
guaA
GMP synthetase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.
 
  
 0.924
PAE0563
ADP ribose hydrolase, putative (mutT/nudix family protein); DNA metabolism; DNA replication, recombination, and repair.
  
 
 0.921
PAE1927
Transketolase (C terminal section); Energy metabolism; Pentose phosphate pathway.
    
  0.921
PAE1929
Transketolase (N terminal section); Energy metabolism; Pentose phosphate pathway.
    
 0.918
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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