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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (284 aa)    
Predicted Functional Partners:
PAE2646
Pyruvate dehydrogenase E1 beta subunit; Energy metabolism; Glycolysis/gluconeogenesis.
  
 0.979
PAE2648
Pyruvate dehydrogenase E2 (dihydrolipoamide acetyltransferase); Energy metabolism; Glycolysis/gluconeogenesis.
 
 0.974
guaA
GMP synthetase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.
 
  
 0.949
PAE1027
Ribose 5-phosphate isomerase; Energy metabolism; Pentose phosphate pathway.
  
 
 0.941
PAE0218
Amidophosphoribosyltransferase (purF); Purines, pyrimidines, nucleosides, and nucleotides; Purine ribonucleotide biosynthesis.
  
 0.936
PAE0226
Amidophosphoribosyltransferase (purF); Purines, pyrimidines, nucleosides, and nucleotides; Purine ribonucleotide biosynthesis; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 0.936
PAE2623
Mercuric reductase; Cellular processes; Toxin production and resistance; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
 
 0.936
PAE2649
Pyruvate dehydrogenase E3 (dihydrolipoamide dehydrogenase); Energy metabolism; Glycolysis/gluconeogenesis.
 
 0.935
PAE0563
ADP ribose hydrolase, putative (mutT/nudix family protein); DNA metabolism; DNA replication, recombination, and repair.
    
 0.913
hisG
ATP phosphoribosyltransferase (hisG); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
  
 
 0.913
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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