STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gch3Conserved hypothetical protein; Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity; Belongs to the archaeal-type GTP cyclohydrolase family. (221 aa)    
Predicted Functional Partners:
PAE2986
GTP cyclohydrolase II; Biosynthesis of cofactors, prosthetic groups, and carriers; Riboflavin, FMN, and FAD.
 
     0.880
PAE2985
Riboflavin specific deaminase, putative; Biosynthesis of cofactors, prosthetic groups, and carriers; Riboflavin, FMN, and FAD.
 
     0.871
PAE0832
Adenylate cyclase; Purines, pyrimidines, nucleosides, and nucleotides; Purine ribonucleotide biosynthesis.
  
  
  0.833
ndk
Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).
    
  0.801
pyk
Pyruvate kinase; Energy metabolism; Glycolysis/gluconeogenesis; Belongs to the pyruvate kinase family.
     
  0.800
PAE2983
Conserved hypothetical protein.
 
   
 0.744
PAE0309
Chlorohydrolase, conjectural; Unclassified.
 
     0.683
hjc
Holliday Junction Resolvase; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family.
  
     0.680
PAE0628
Conserved hypothetical protein.
  
     0.602
fau-1
Conserved hypothetical protein; Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.
  
     0.537
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.