STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAE2985Riboflavin specific deaminase, putative; Biosynthesis of cofactors, prosthetic groups, and carriers; Riboflavin, FMN, and FAD. (227 aa)    
Predicted Functional Partners:
PAE2986
GTP cyclohydrolase II; Biosynthesis of cofactors, prosthetic groups, and carriers; Riboflavin, FMN, and FAD.
 
 
 0.992
ribH
Riboflavin synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
 
 0.965
gch3
Conserved hypothetical protein; Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity; Belongs to the archaeal-type GTP cyclohydrolase family.
 
     0.871
PAE2983
Conserved hypothetical protein.
     
 0.748
PAE3114
Nicotinate-nucleotide pyrophosphorylase AND conserved protein; Biosynthesis of cofactors, prosthetic groups, and carriers; Pyridine nucleotides.
 
 
 
 0.717
PAE1861
Hypothetical protein with 4 ankyrin repeats; Unclassified.
  
 
 0.714
PAE2937
Dihydropteroate synthase; Biosynthesis of cofactors, prosthetic groups, and carriers; Folic acid.
 
   
 0.672
guaA
GMP synthetase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.
     
 0.610
prf1
Peptide chain release factor aRF subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
   
   0.587
PAE2758
Cation-transporting ATPase (P-type); Transport and binding proteins; Cations.
  
  
 0.577
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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