STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Cooccurrence
Coexpression
Experiments
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[Homology]
Score
PAE2986GTP cyclohydrolase II; Biosynthesis of cofactors, prosthetic groups, and carriers; Riboflavin, FMN, and FAD. (213 aa)    
Predicted Functional Partners:
ribH
Riboflavin synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
 
 0.999
PAE2985
Riboflavin specific deaminase, putative; Biosynthesis of cofactors, prosthetic groups, and carriers; Riboflavin, FMN, and FAD.
 
 
 0.991
gch3
Conserved hypothetical protein; Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity; Belongs to the archaeal-type GTP cyclohydrolase family.
 
     0.935
PAE2021
Conserved hypothetical protein.
 
   
 0.867
guaA
GMP synthetase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.
  
  
 0.748
PAE0309
Chlorohydrolase, conjectural; Unclassified.
 
     0.722
PAE2983
Conserved hypothetical protein.
     
 0.679
rps2
Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the universal ribosomal protein uS2 family.
  
  
 0.652
PAE0683
Cytidyltransferase; Unclassified.
 
     0.559
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
  
 0.512
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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