Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE3083Asparaginase; Energy metabolism; Amino acids and amines. (299 aa)    
Predicted Functional Partners:
PAE0376
Asparagine synthetase (asnB); Amino acid biosynthesis; Aspartate family.
  
  
 0.931
purA
Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
    
  0.920
PAE1964
Aspartate aminotransferase (aspC), conjectural; Amino acid biosynthesis; Aspartate family.
    
 0.910
PAE2251
Aspartate aminotransferase (aspC), conjectural; Amino acid biosynthesis; Aspartate family.
    
 0.910
pyrB
Aspartate carbamoyltransferase catalytic subunit (pyrB); Purines, pyrimidines, nucleosides, and nucleotides; Pyrimidine ribonucleotide biosynthesis.
    
  0.903
pyrI
Aspartate carbamoyltransferase, regulatory subunit (pyrI); Involved in allosteric regulation of aspartate carbamoyltransferase.
    
  0.901
argG
Argininosuccinate synthase (argG); Amino acid biosynthesis; Glutamate family; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
     
 0.900
PAE2877
Aspartate kinase; Amino acid biosynthesis; Aspartate family.
    
 0.834
rps4
Ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
       0.798
rps13
Ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family.
     
 0.752
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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