STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Cooccurrence
Coexpression
Experiments
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[Homology]
Score
nadAQuinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (307 aa)    
Predicted Functional Partners:
PAE3114
Nicotinate-nucleotide pyrophosphorylase AND conserved protein; Biosynthesis of cofactors, prosthetic groups, and carriers; Pyridine nucleotides.
 
 
 0.999
guaA
GMP synthetase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.
     
 0.704
PAE3116
Conserved hypothetical protein.
     
 0.597
PAE3117
Small heat shock protein, hsp20 homolog, conjectural; Cellular processes; Adaptations to atypical conditions; Belongs to the small heat shock protein (HSP20) family.
     
 0.530
nadE
NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
  
  
 0.497
tmk
Thymidylate kinase (tmk); Purines, pyrimidines, nucleosides, and nucleotides; Nucleotide and nucleoside interconversions.
     
 0.492
PAE3118
Ribose ABC transporter, permease protein; Transport and binding proteins; Carbohydrates, organic alcohols, and acids.
       0.491
PAE3119
Ribose ABC transporter, permease protein; Transport and binding proteins; Carbohydrates, organic alcohols, and acids.
       0.491
PAE3120
Ribose ABC transport system ATP-binding; Transport and binding proteins; Carbohydrates, organic alcohols, and acids.
       0.490
PAE3121
Transport and binding proteins; Carbohydrates, organic alcohols, and acids.
       0.485
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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