STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nadAQuinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (307 aa)    
Predicted Functional Partners:
PAE3114
Nicotinate-nucleotide pyrophosphorylase AND conserved protein; Biosynthesis of cofactors, prosthetic groups, and carriers; Pyridine nucleotides.
 
 
 0.999
nadE
NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
  
  
 0.635
guaA
GMP synthetase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.
     
 0.634
PAE3116
Conserved hypothetical protein.
     
 0.617
PAE3117
Small heat shock protein, hsp20 homolog, conjectural; Cellular processes; Adaptations to atypical conditions; Belongs to the small heat shock protein (HSP20) family.
     
 0.575
queE
Coenzyme PQQ synthesis protein, conjectural; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
 
   
 0.549
thiC
Thiamine biosynthesis protein (thiC); Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.498
PAE3118
Ribose ABC transporter, permease protein; Transport and binding proteins; Carbohydrates, organic alcohols, and acids.
       0.491
PAE3119
Ribose ABC transporter, permease protein; Transport and binding proteins; Carbohydrates, organic alcohols, and acids.
       0.491
PAE3120
Ribose ABC transport system ATP-binding; Transport and binding proteins; Carbohydrates, organic alcohols, and acids.
       0.491
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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