Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PAE3125P. aerophilum family 70 protein; Hypothetical; Conserved within genome. (177 aa)    
Predicted Functional Partners:
PAE3127
P. aerophilum family 68 protein, part 2, authentic frameshift; Hypothetical; Conserved within genome.
       0.773
PAE3123
Hypothetical protein.
       0.556
PAE3124
Penicillin amidase; Unclassified.
       0.556
PAE3129
P. aerophilum family 68 protein, part 1, authentic frameshift; Hypothetical; Conserved within genome.
       0.532
PAE3118
Ribose ABC transporter, permease protein; Transport and binding proteins; Carbohydrates, organic alcohols, and acids.
       0.514
PAE3119
Ribose ABC transporter, permease protein; Transport and binding proteins; Carbohydrates, organic alcohols, and acids.
       0.514
PAE3120
Ribose ABC transport system ATP-binding; Transport and binding proteins; Carbohydrates, organic alcohols, and acids.
       0.514
PAE3121
Transport and binding proteins; Carbohydrates, organic alcohols, and acids.
       0.514
PAE3116
Conserved hypothetical protein.
       0.466
PAE3117
Small heat shock protein, hsp20 homolog, conjectural; Cellular processes; Adaptations to atypical conditions; Belongs to the small heat shock protein (HSP20) family.
       0.466
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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