Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ahcYAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (437 aa)    
Predicted Functional Partners:
PAE3655
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Amino acid biosynthesis; Aspartate family.
  
 
 0.978
PAE2420
Cystathionine gamma-synthase; Amino acid biosynthesis; Aspartate family.
  
 0.948
PAE1659
C-5 cytosine-specific DNA methylase; DNA metabolism; DNA replication, recombination, and repair; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
    
 0.914
PAE3201
C-5 cytosine-specific DNA methylase; DNA metabolism; DNA replication, recombination, and repair; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
    
 0.914
PAE2868
Homoserine dehydrogenase; Amino acid biosynthesis; Aspartate family.
  
 
 0.845
PAE2316
Threonine dehydratase (ilvA); Amino acid biosynthesis; Pyruvate family.
  
 
 0.835
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
  
 
  0.821
PAE2730
Selenium binding protein, probable; Transport and binding proteins; Other.
     
  0.800
guaA
GMP synthetase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.
  
 
 0.778
PAE2024
Conserved hypothetical protein.
  
 
 0.730
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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