Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
PAE3249Conserved hypothetical protein. (232 aa)    
Predicted Functional Partners:
PAE3250
Conserved hypothetical protein.
 
 0.999
PAE2895
Conserved hypothetical protein, authentic frameshift.
 
 
 0.995
acsA
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
    
 0.939
PAE0939
2-oxoacid ferredoxin oxidoreductase alpha subunit; Energy metabolism; Electron transport.
  
 0.933
PAE1042
Pyruvate ferredoxin oxidoreductase alpha subunit (porA); Energy metabolism; Fermentation.
  
 0.933
PAE1559
2-oxoacid ferredoxin oxidoreductase alpha subunit; Energy metabolism; Electron transport.
  
 0.933
PAE2736
2-oxoacid ferredoxin oxidoreductase alpha subunit; Energy metabolism; Electron transport.
  
 0.933
PAE3275
2-ketoacid ferredoxin oxidoreductase alpha subunit; Energy metabolism; Fermentation.
  
 0.933
PAE2481
Acetyl-coenzyme A synthetase; Fatty acid and phospholipid metabolism; Degradation.
    
 0.920
PAE2480
Aldehyde dehydrogenase; Unclassified.
    
 0.918
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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