STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAE3263Dihydroorotate dehydrogenase (pyrD); Purines, pyrimidines, nucleosides, and nucleotides; Pyrimidine ribonucleotide biosynthesis. (297 aa)    
Predicted Functional Partners:
pyrC
Dihydroorotase (pyrC); Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 
 0.999
pyrE
Orotate phosphoribosyltransferase (pyrE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
 
 0.999
carB
Carbamoyl-phosphate synthase large subunit; Purines, pyrimidines, nucleosides, and nucleotides; Pyrimidine ribonucleotide biosynthesis.
 
 
 0.994
pyrB
Aspartate carbamoyltransferase catalytic subunit (pyrB); Purines, pyrimidines, nucleosides, and nucleotides; Pyrimidine ribonucleotide biosynthesis.
 
  
 0.993
carA
Carbamoyl-phosphate synthase small subunit; Purines, pyrimidines, nucleosides, and nucleotides; Pyrimidine ribonucleotide biosynthesis; Belongs to the CarA family.
 
  
 0.992
PAE0768
Orotidine-5'-monophosphate decarboxylase (pyrF); Purines, pyrimidines, nucleosides, and nucleotides; Pyrimidine ribonucleotide biosynthesis.
  
  
 0.991
pyrI
Aspartate carbamoyltransferase, regulatory subunit (pyrI); Involved in allosteric regulation of aspartate carbamoyltransferase.
  
  
 0.938
guaA
GMP synthetase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.
 
 
 0.902
PAE3227
Glutamate synthase small subunit gltD; Amino acid biosynthesis; Glutamate family.
  
 
 0.781
PAE2942a
methionyl-tRNA synthetase beta subunit; Protein synthesis; tRNA aminoacylation.
  
  
 0.729
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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