Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE3281UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase, conjectural; Cell envelope; Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (449 aa)    
Predicted Functional Partners:
PAE2053
Pleiotropic regulatory protein, conjectural; Regulatory functions; General; Belongs to the DegT/DnrJ/EryC1 family.
 
  
 0.924
PAE0870
Conserved NAD/P oxidoreductase; Unclassified.
 
  
 0.860
PAE1472
Acetyl/acyl transferase related protein; Fatty acid and phospholipid metabolism; Biosynthesis.
 
   
 0.810
PAE1922
UDP-glucose 4-epimerase (galE-1); Cell envelope; Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides.
  
 0.799
PAE3488
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; Cell envelope; Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides.
 
  
 0.766
PAE2970
Conserved hypothetical protein.
 
   
 0.626
PAE3282
Conserved hypothetical protein.
       0.605
PAE1143
Conserved protein (acetyltransferase); Unclassified.
 
  
 0.489
PAE3631
NAD dependent epimerase/dehydratase, putative; Purines, pyrimidines, nucleosides, and nucleotides; Sugar-nucleotide biosynthesis and conversions.
  
  
 0.475
hisF
Histidine biosynthesis protein (hisF,cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
    0.466
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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