Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE3292Conserved hypothetical protein; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family. (173 aa)    
Predicted Functional Partners:
ndk
Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).
    
 0.959
PAE2535
Phosphomethylpyrimidine kinase; Biosynthesis of cofactors, prosthetic groups, and carriers; Thiamine.
     
 0.906
PAE0832
Adenylate cyclase; Purines, pyrimidines, nucleosides, and nucleotides; Purine ribonucleotide biosynthesis.
     
  0.900
PAE1022
Thiamine-monophosphate kinase part 2, authentic frameshift; Biosynthesis of cofactors, prosthetic groups, and carriers; Thiamine.
     
  0.900
PAE1024
Thiamine-monophosphate kinase part 1, authentic frameshift; Biosynthesis of cofactors, prosthetic groups, and carriers; Thiamine.
     
  0.900
adkA
Adenylate kinase; Purines, pyrimidines, nucleosides, and nucleotides; Nucleotide and nucleoside interconversions; Belongs to the archaeal adenylate kinase family.
     
  0.900
PAE2951
Hypothetical protein.
     
  0.900
PAE2972
Conserved hypothetical protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily.
     
  0.900
PAE3155
Ribonucleotide reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
     
  0.900
trm1
N2,N2-dimethylguonasine tRNA methyltransferase; Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
 
 
 
 0.852
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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