Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE3299Acetolactate synthase small subunit; Amino acid biosynthesis; Pyruvate family. (75 aa)    
Predicted Functional Partners:
ilvC
Acetohydroxy acid isomeroreductase (ilvC); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
    
  0.990
PAE3300
Acetolactate synthase large subunit (ilvB); Amino acid biosynthesis; Pyruvate family.
    
  0.986
PAE1995
3-isopropylmalate dehydrogenase (leuB); Amino acid biosynthesis; Pyruvate family.
    
  0.903
PAE0938
2-oxoacid ferredoxin oxidoreductase beta subunit; Energy metabolism; Electron transport.
     
  0.900
PAE0939
2-oxoacid ferredoxin oxidoreductase alpha subunit; Energy metabolism; Electron transport.
     
  0.900
PAE1040
Pyruvate ferredoxin oxidoreductase gamma subunit (porG); Energy metabolism; Fermentation.
     
  0.900
PAE1041
Pyruvate ferredoxin oxidoreductase delta subunit (porD); Energy metabolism; Fermentation.
     
  0.900
PAE1042
Pyruvate ferredoxin oxidoreductase alpha subunit (porA); Energy metabolism; Fermentation.
     
  0.900
PAE1043
Pyruvate ferredoxin oxidoreductase beta subunit (porB); Energy metabolism; Fermentation.
     
  0.900
PAE1558
2-oxoacid ferredoxin oxidoreductase beta subunit; Energy metabolism; Electron transport.
     
  0.900
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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