Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
PAE3406Conserved hypothetical protein. (255 aa)    
Predicted Functional Partners:
PAE3407
Conserved hypothetical protein.
 
  
 0.994
PAE1204
Pantothenate metabolism flavoprotein (dfp); DNA metabolism; DNA replication, recombination, and repair.
 
  
 0.966
PAE2480
Aldehyde dehydrogenase; Unclassified.
  
  
  0.913
PAE1799
4-aminobutyrate aminotransferase; Amino acid biosynthesis; Glutamate family; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
     
  0.900
PAE3409
2-dehydropantoate 2-reductase (ketopantoate reductase); Catalyzes the NAD(P)H-dependent reduction of ketopantoate into pantoic acid.
 
   
 0.684
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
     
 0.623
PAE1653
Conserved hypothetical protein.
 
     0.620
PAE1632
Conserved hypothetical protein; Belongs to the UPF0201 family.
 
   
 0.612
PAE2050
Conserved hypothetical protein.
 
     0.586
tiaS
Conserved hypothetical protein; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
 
     0.582
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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