Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-expression
Experiments
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[Homology]
Score
PAE3407Conserved hypothetical protein. (259 aa)    
Predicted Functional Partners:
PAE3406
Conserved hypothetical protein.
 
  
 0.994
PAE3409
2-dehydropantoate 2-reductase (ketopantoate reductase); Catalyzes the NAD(P)H-dependent reduction of ketopantoate into pantoic acid.
 
  
 0.992
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
  
    0.798
PAE3655
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Amino acid biosynthesis; Aspartate family.
  
    0.786
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
     
 0.772
PAE3193a
Possible heat shock protein, htpX homolog part 1, authentic frameshift; Cellular processes; Adaptations to atypical conditions.
  
    0.698
PAE3195
Possible heat shock protein, htpX homolog part 2, authentic frameshift; Cellular processes; Adaptations to atypical conditions.
  
    0.698
htpX
Heat shock protein, htpX homolog, conjectural; Cellular processes; Adaptations to atypical conditions; Belongs to the peptidase M48B family.
  
    0.698
PAE2317
alanyl-tRNA synthetase related protein; Protein synthesis; tRNA aminoacylation.
  
    0.651
PAE1688
Malate oxidoreductase (mae); Energy metabolism; Other.
  
    0.645
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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