Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ppcAConserved hypothetical protein; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. (460 aa)    
Predicted Functional Partners:
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily.
     
 0.946
pyk
Pyruvate kinase; Energy metabolism; Glycolysis/gluconeogenesis; Belongs to the pyruvate kinase family.
     
 0.945
PAE2423
Phosphoenolpyruvate synthase (pyruvate,water dikinase); Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
     
 0.915
PAE3383
Pyruvate, phosphate dikinase; Energy metabolism; Other.
     
 0.915
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
     
  0.900
PAE2662
Formate dehydrogenase alpha subunit; Energy metabolism; Electron transport.
  
  
  0.893
PAE1689
Citrate synthase; Energy metabolism; TCA cycle.
     
 0.830
PAE3584
Citrate synthase part 1, authentic frameshift; Energy metabolism; TCA cycle.
     
 0.830
PAE3585
Citrate synthase part 2, authentic frameshift; Energy metabolism; TCA cycle.
     
 0.830
apgM
Phosphonopyruvate decarboxylase, conjectural; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
     
 0.826
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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