Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE3437Glucokinase (ROK family protein), conjectural; Energy metabolism; Sugars. (296 aa)    
Predicted Functional Partners:
PAE1610
Glucose-6-phosphate isomerase, conjectural; Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency.
 
 
 0.956
PAE1761
Myo-inositol-1-phosphate synthase, conjectural; Fatty acid and phospholipid metabolism; Other.
     
 0.901
fbp
Conserved hypothetical protein; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
    
 0.899
PAE1309
Conserved hypothetical protein.
    
  0.822
deoC
Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
    
  0.815
PAE1929
Transketolase (N terminal section); Energy metabolism; Pentose phosphate pathway.
    
 0.811
PAE1927
Transketolase (C terminal section); Energy metabolism; Pentose phosphate pathway.
    
  0.803
PAE0835
Sugar kinase, possible phosphofructokinase; Energy metabolism; Glycolysis/gluconeogenesis; Belongs to the carbohydrate kinase PfkB family.
 
  
 0.709
PAE3435
Preprotein translocase secY subunit; Protein fate; Protein and peptide secretion and trafficking; Belongs to the SecY/SEC61-alpha family.
       0.673
rpl15
Ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.
       0.669
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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