Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE3444Glutamate synthase subunit, conjectural; Amino acid biosynthesis; Glutamate family. (689 aa)    
Predicted Functional Partners:
PAE3227
Glutamate synthase small subunit gltD; Amino acid biosynthesis; Glutamate family.
 
 0.998
PAE3443
Glutamate synthase subunit, conjectural; Amino acid biosynthesis; Glutamate family.
 
 
 0.993
guaA
GMP synthetase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.
  
  
 0.885
PAE1996
Amino acid biosynthesis; Glutamate family; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.781
PAE3438
Amino acid biosynthesis; Glutamate family; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.781
rpl14
Ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family.
   
 
 0.716
tfb
Transcription initiation factor IIB (TFIIB); Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
    
   0.655
PAE2120
Transcription initiation factor IIB, conjectural; Transcription; Transcription factors.
    
   0.655
PAE3329
Transcription initiation factor IIB (TFIIB); Transcription; Transcription factors.
    
   0.655
PAE3442
Glutamine synthetase; Amino acid biosynthesis; Glutamate family; Belongs to the glutamine synthetase family.
  
  
 0.640
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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