Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE3447Aminotransferase, class-V; Unclassified. (384 aa)    
Predicted Functional Partners:
fni
Conserved protein (possible oxidoreductase); Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
  
 0.795
PAE3450
Hypothetical protein.
       0.789
PAE3445
Hypothetical; Conserved within genome.
       0.773
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
  
  
 0.695
purD
Phosphoribosylglycinamide synthetase (GARS) (purD); Purines, pyrimidines, nucleosides, and nucleotides; Purine ribonucleotide biosynthesis; Belongs to the GARS family.
  
  
 0.687
PAE3300
Acetolactate synthase large subunit (ilvB); Amino acid biosynthesis; Pyruvate family.
  
 
 0.670
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
 
  
 0.668
PAE2317
alanyl-tRNA synthetase related protein; Protein synthesis; tRNA aminoacylation.
  
  
 0.631
PAE1651
Isocitrate dehydrogenase; Energy metabolism; TCA cycle.
   
 
 0.601
PAE1543
Conserved hypothetical protein.
  
 
 0.598
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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