Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-expression
Experiments
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[Homology]
Score
PAE3561Conserved hypothetical protein. (110 aa)    
Predicted Functional Partners:
PAE3473
Conserved hypothetical protein.
   
 0.982
PAE3232
Nop family pre-rRNA processing protein; Transcription; RNA processing.
   
 
 0.920
PAE3330
Hypothetical protein.
   
 
 0.875
rpl7ae
Ribosomal protein L7; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
  
 
 0.856
nep1
Conserved hypothetical protein; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
   
 0.849
truB
tRNA pseudouridine synthase B; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
   
 
 0.828
PAE3562
DNA-directed RNA polymerase subunit E' (rpoE1); Transcription; DNA-dependent RNA polymerase.
  
  
 0.813
PAE3560
Hypothetical protein.
       0.799
PAE3559
HIT family protein; Unclassified.
       0.795
nop10
Conserved hypothetical protein; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.
   
 
 0.786
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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