STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAE3585Citrate synthase part 2, authentic frameshift; Energy metabolism; TCA cycle. (51 aa)    
Predicted Functional Partners:
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily.
  
 0.988
PAE1499
Aconitate hydratase; Energy metabolism; TCA cycle.
  
 0.986
PAE2648
Pyruvate dehydrogenase E2 (dihydrolipoamide acetyltransferase); Energy metabolism; Glycolysis/gluconeogenesis.
  
 0.982
PAE3584
Citrate synthase part 1, authentic frameshift; Energy metabolism; TCA cycle.
 
  
  0.979
PAE2481
Acetyl-coenzyme A synthetase; Fatty acid and phospholipid metabolism; Degradation.
  
 0.967
PAE2865
Acetyl-coenzyme A synthetase; Fatty acid and phospholipid metabolism; Degradation.
  
 0.967
acsA
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 0.967
PAE1287
Malate synthase (glcB); Central intermediary metabolism; Other.
  
 0.966
PAE1220
acetyl-CoA C-acetyltransferase; Fatty acid and phospholipid metabolism; Degradation.
  
 0.938
PAE1377
acetyl-CoA C-acyltransferase; Fatty acid and phospholipid metabolism; Degradation.
  
 0.938
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.