Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAE3592Acetyl-coenzyme A synthetase, degenerate; Fatty acid and phospholipid metabolism; Degradation. (256 aa)    
Predicted Functional Partners:
PAE1996
Amino acid biosynthesis; Glutamate family; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.547
PAE3438
Amino acid biosynthesis; Glutamate family; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.547
cobB1
Conserved hypothetical protein; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily.
   
 0.532
cobB2
Conserved hypothetical protein; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily.
   
 0.532
guaA
GMP synthetase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.
  
  
 0.522
PAE1651
Isocitrate dehydrogenase; Energy metabolism; TCA cycle.
   
 
 0.507
prpB
Carboxyphosphonoenolpyruvate phosphonomutase (prpB); Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
  
  
 0.491
PAE1872
Isocitrate lyase; Central intermediary metabolism; Other.
  
  
 0.491
PAE1287
Malate synthase (glcB); Central intermediary metabolism; Other.
  
 
 0.476
sod
Superoxide dismutase (sod); Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family.
  
 
 0.473
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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