STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AOS46849.1Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (486 aa)    
Predicted Functional Partners:
AOS46623.1
Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.887
AOS46850.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.634
whiB
WhiB family transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
  
     0.570
whiB-3
Transcription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
 
   
 0.502
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
       0.433
AOS46852.1
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
       0.427
AOS47569.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.426
AOS47592.1
MATE family efflux transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   
 0.418
whiB-2
WhiB family transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
  
     0.412
Your Current Organism:
Actinomyces hongkongensis
NCBI taxonomy Id: 178339
Other names: A. hongkongensis, Actinomyces hongkongensis Woo et al. 2004, CCUG 48484, CIP 107949, DSM 15629, LMG 21939, LMG:21939, strain HKU8
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