AWU55_2518 protein (Halomonadaceae bacterium T822)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

AWU55_2518

Hypothetical protein; Scaffold_39_55. (169 aa)

Predicted Functional Partners:

AWU55_2136

0.733

AWU55_622

0.701

AWU55_144

0.665

AWU55_195

0.643

AWU55_2517

0.630

AWU55_2311

0.589

AWU55_1179

0.578

AWU55_1539

0.578

AWU55_2744

0.539

dnaK

0.522

Your Current Organism:

Halomonadaceae bacterium T822

NCBI taxonomy Id: 1783518
Other names: H. bacterium T82-2, Halomonadaceae bacterium T82-2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AWU55_1179	AWU55_144	AWU55_1179	AWU55_144	Hypothetical protein; Scaffold_5_100.	Hypothetical protein; Scaffold_0_144.	0.485
AWU55_1179	AWU55_2311	AWU55_1179	AWU55_2311	Hypothetical protein; Scaffold_5_100.	Hypothetical protein; Scaffold_30_23.	0.662
AWU55_1179	AWU55_2518	AWU55_1179	AWU55_2518	Hypothetical protein; Scaffold_5_100.	Hypothetical protein; Scaffold_39_55.	0.578
AWU55_1179	AWU55_622	AWU55_1179	AWU55_622	Hypothetical protein; Scaffold_5_100.	Hypothetical protein; Scaffold_2_34.	0.484
AWU55_144	AWU55_1179	AWU55_144	AWU55_1179	Hypothetical protein; Scaffold_0_144.	Hypothetical protein; Scaffold_5_100.	0.485
AWU55_144	AWU55_1539	AWU55_144	AWU55_1539	Hypothetical protein; Scaffold_0_144.	Multi-sensor hybrid histidine kinase; Scaffold_9_60.	0.743
AWU55_144	AWU55_195	AWU55_144	AWU55_195	Hypothetical protein; Scaffold_0_144.	Multi-sensor hybrid histidine kinase; Scaffold_0_195.	0.706
AWU55_144	AWU55_2311	AWU55_144	AWU55_2311	Hypothetical protein; Scaffold_0_144.	Hypothetical protein; Scaffold_30_23.	0.607
AWU55_144	AWU55_2518	AWU55_144	AWU55_2518	Hypothetical protein; Scaffold_0_144.	Hypothetical protein; Scaffold_39_55.	0.665
AWU55_144	AWU55_2744	AWU55_144	AWU55_2744	Hypothetical protein; Scaffold_0_144.	Hypothetical protein; Scaffold_66_8.	0.705
AWU55_144	AWU55_622	AWU55_144	AWU55_622	Hypothetical protein; Scaffold_0_144.	Hypothetical protein; Scaffold_2_34.	0.722
AWU55_1539	AWU55_144	AWU55_1539	AWU55_144	Multi-sensor hybrid histidine kinase; Scaffold_9_60.	Hypothetical protein; Scaffold_0_144.	0.743
AWU55_1539	AWU55_195	AWU55_1539	AWU55_195	Multi-sensor hybrid histidine kinase; Scaffold_9_60.	Multi-sensor hybrid histidine kinase; Scaffold_0_195.	0.999
AWU55_1539	AWU55_2311	AWU55_1539	AWU55_2311	Multi-sensor hybrid histidine kinase; Scaffold_9_60.	Hypothetical protein; Scaffold_30_23.	0.834
AWU55_1539	AWU55_2518	AWU55_1539	AWU55_2518	Multi-sensor hybrid histidine kinase; Scaffold_9_60.	Hypothetical protein; Scaffold_39_55.	0.578
AWU55_1539	dnaK	AWU55_1539	AWU55_2569	Multi-sensor hybrid histidine kinase; Scaffold_9_60.	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.615
AWU55_195	AWU55_144	AWU55_195	AWU55_144	Multi-sensor hybrid histidine kinase; Scaffold_0_195.	Hypothetical protein; Scaffold_0_144.	0.706
AWU55_195	AWU55_1539	AWU55_195	AWU55_1539	Multi-sensor hybrid histidine kinase; Scaffold_0_195.	Multi-sensor hybrid histidine kinase; Scaffold_9_60.	0.999
AWU55_195	AWU55_2136	AWU55_195	AWU55_2136	Multi-sensor hybrid histidine kinase; Scaffold_0_195.	Proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.	0.964
AWU55_195	AWU55_2311	AWU55_195	AWU55_2311	Multi-sensor hybrid histidine kinase; Scaffold_0_195.	Hypothetical protein; Scaffold_30_23.	0.749

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.936

expected number of edges:

52

PPI enrichment p-value:

0.997

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

7 of 392

1.63

2.47

1.99e-07

GO:0042128

Nitrate assimilation

2 of 16

2.48

1.26

0.0049

GO:0006807

Nitrogen compound metabolic process

9 of 5018

0.63

0.48

0.0031

GO:0044237

Cellular metabolic process

9 of 5407

0.6

0.44

0.0049

GO:0071704

Organic substance metabolic process

9 of 6797

0.5

0.34

0.0253

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

7 of 209

1.9

3.64

1.23e-09

GO:0050464

Nitrate reductase (NADPH) activity

2 of 2

3.38

1.82

0.00053

GO:0043546

Molybdopterin cofactor binding

2 of 5

2.98

1.74

0.00070

GO:0070181

Small ribosomal subunit rRNA binding

2 of 6

2.9

1.7

0.00083

GO:0019843

rRNA binding

3 of 54

2.12

1.69

0.00053

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005763

Mitochondrial small ribosomal subunit

7 of 27

2.79

7.8

8.27e-16

GO:0110165

Cellular anatomical entity

11 of 13713

0.28

0.23

0.0349

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10412

Organellar ribosome, and Nucleoside diphosphate kinase-like domain

7 of 67

2.4

5.8

9.30e-13

CL:10424

Organellar large ribosomal subunit, and Organellar small ribosomal subunit

4 of 28

2.53

3.58

1.47e-07

CL:10505

Mixed, incl. Small ribosomal subunit rRNA binding, and Ribosomal protein S5

3 of 7

3.01

3.23

1.27e-06

CL:10427

Organellar large ribosomal subunit, and 5S rRNA binding

3 of 21

2.53

2.51

2.00e-05

CL:18134

Nitrate reductase activity, and Sterol desaturase Scs7

2 of 5

2.98

1.8

0.00054

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

6 of 246

1.77

2.89

4.90e-08

map00910

Nitrogen metabolism

2 of 84

1.76

0.71

0.0433

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72766

Translation

7 of 413

1.61

2.52

7.47e-08

MAP-392499

Metabolism of proteins

7 of 1640

1.01

0.9

0.00047

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005763

Mitochondrial small ribosomal subunit

7 of 31

2.73

7.49

2.46e-15

GOCC:0110165

Cellular anatomical entity

11 of 12503

0.32

0.26

0.0160

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

3 of 117

1.79

1.21

0.0036

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03404

Mo-co oxidoreductase dimerisation domain

2 of 4

3.08

1.37

0.0034

PF00174

Oxidoreductase molybdopterin binding domain

2 of 4

3.08

1.37

0.0034

PF00970

Oxidoreductase FAD-binding domain

2 of 7

2.83

1.36

0.0034

PF00175

Oxidoreductase NAD-binding domain

2 of 21

2.36

1.01

0.0141

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036374

Oxidoreductase, molybdopterin-binding domain superfamily

2 of 4

3.08

1.14

0.0089

IPR008335

Eukaryotic molybdopterin oxidoreductase

2 of 4

3.08

1.14

0.0089

IPR005066

Moybdenum cofactor oxidoreductase, dimerisation

2 of 4

3.08

1.14

0.0089

IPR000572

Oxidoreductase, molybdopterin-binding domain

2 of 4

3.08

1.14

0.0089

IPR008333

Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain

2 of 7

2.83

1.13

0.0089

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

2 of 25

2.28

0.91

0.0208

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