STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
prpBMethylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (293 aa)    
Predicted Functional Partners:
AWU55_557
2-methylcitrate synthase; Scaffold_1_188; Belongs to the citrate synthase family.
 0.997
AWU55_556
2-methylcitrate dehydratase; Scaffold_1_187.
 
 
 0.989
AWU55_1576
Citrate synthase; Scaffold_9_97; Belongs to the citrate synthase family.
 
 0.966
AWU55_653
Bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Scaffold_2_65.
  
 
 0.949
acsA
acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
 0.927
AWU55_514
MmgE/PrpD; Scaffold_1_145.
  
 
 0.919
sucD
succinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
    
 0.900
AWU55_666
Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
    
  0.895
AWU55_892
Aconitate hydratase 2 / 2-methylisocitrate dehydratase; Scaffold_3_101; Belongs to the aconitase/IPM isomerase family.
     
 0.894
AWU55_570
acetyl-CoA C-acetyltransferase; Scaffold_1_201; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.888
Your Current Organism:
Halomonadaceae bacterium T822
NCBI taxonomy Id: 1783518
Other names: H. bacterium T82-2, Halomonadaceae bacterium T82-2
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