Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mcaGlcNAc-PI de-N-acetylase; A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S- conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics; Belongs to the MshB deacetylase family. Mca subfamily. (290 aa)    
Predicted Functional Partners:
AMP22737.1
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.875
AMP22738.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.875
mshD
Mycothiol acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
  
   
 0.874
mshA
Diguanylate cyclase; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
 
  
 0.830
mshC
cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
 
  
 0.814
AMP22367.1
DSBA oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.784
AMP25992.1
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.766
AMP24173.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.757
AMP26323.1
Glutaredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   
 0.657
AMP25112.1
Catalyzes the reduction of mycothione or glutathione to mycothione or glutathione disulfide; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   
 0.629
Your Current Organism:
Mycobacterium simiae
NCBI taxonomy Id: 1784
Other names: ATCC 25275, CCUG 29114, CCUG 42427, CIP 104531, DSM 44165, JCM 12377, M. simiae, Mycobacterium habana
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