AMP22930.1 protein (Mycobacterium simiae) - STRING interaction network

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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[Homology]

Score

AMP22930.1

enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)

Predicted Functional Partners:

AMP22926.1

0.989

AMP22927.1

0.988

AMP22395.1

0.974

AMP22929.1

0.964

AMP22928.1

0.954

AMP23063.1

0.931

AMP24260.1

0.930

AMP22393.1

0.924

AMP22493.1

0.924

AMP23828.1

0.924

Your Current Organism:

Mycobacterium simiae

NCBI taxonomy Id: 1784
Other names: ATCC 25275, CCUG 29114, CCUG 42427, CIP 104531, DSM 44165, JCM 12377, M. simiae, Mycobacterium habana

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMP22393.1	AMP22395.1	VC42_06125	VC42_06135	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	methylcrotonoyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.987
AMP22393.1	AMP22927.1	VC42_06125	VC42_09450	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.408
AMP22393.1	AMP22930.1	VC42_06125	VC42_09465	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.924
AMP22393.1	AMP23063.1	VC42_06125	VC42_10355	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.965
AMP22393.1	AMP24260.1	VC42_06125	VC42_17900	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-hydroxybutyryl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.571
AMP22395.1	AMP22393.1	VC42_06135	VC42_06125	methylcrotonoyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.987
AMP22395.1	AMP22493.1	VC42_06135	VC42_06745	methylcrotonoyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.402
AMP22395.1	AMP22926.1	VC42_06135	VC42_09445	methylcrotonoyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.912
AMP22395.1	AMP22928.1	VC42_06135	VC42_09455	methylcrotonoyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA carboxylase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.996
AMP22395.1	AMP22929.1	VC42_06135	VC42_09460	methylcrotonoyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.402
AMP22395.1	AMP22930.1	VC42_06135	VC42_09465	methylcrotonoyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.974
AMP22395.1	AMP23063.1	VC42_06135	VC42_10355	methylcrotonoyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.943
AMP22395.1	AMP23828.1	VC42_06135	VC42_15180	methylcrotonoyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.912
AMP22395.1	AMP24260.1	VC42_06135	VC42_17900	methylcrotonoyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-hydroxybutyryl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.498
AMP22493.1	AMP22395.1	VC42_06745	VC42_06135	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	methylcrotonoyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.402
AMP22493.1	AMP22927.1	VC42_06745	VC42_09450	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.402
AMP22493.1	AMP22930.1	VC42_06745	VC42_09465	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.924
AMP22493.1	AMP23063.1	VC42_06745	VC42_10355	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.976
AMP22493.1	AMP24260.1	VC42_06745	VC42_17900	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-hydroxybutyryl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.518
AMP22926.1	AMP22395.1	VC42_09445	VC42_06135	acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	methylcrotonoyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.912

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Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.74

expected number of edges:

15

PPI enrichment p-value:

3.1e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015740

C4-dicarboxylate transport

2 of 2

2.9

1.35

0.0036

GO:0006814

Sodium ion transport

2 of 10

2.2

0.92

0.0200

GO:0071702

Organic substance transport

6 of 546

0.94

0.67

0.0062

GO:0006810

Transport

10 of 1502

0.72

0.61

0.00038

GO:0055085

Transmembrane transport

8 of 1208

0.72

0.52

0.0053

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030246

Carbohydrate binding

3 of 28

1.93

1.12

0.0067

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:16315

Mixed, incl. Bordetella uptake gene, and Protein of unknown function DUF1468

8 of 32

2.3

6.17

2.85e-14

CL:16364

TRAP transporter solute receptor, DctP family, and TRAP transporter large membrane protein DctM

5 of 5

2.9

5.24

1.72e-10

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

8 of 656

0.98

1.01

2.05e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031317

Tripartite ATP-independent periplasmic transporter complex

6 of 6

2.9

6.67

2.67e-13

GOCC:0009317

acetyl-CoA carboxylase complex

2 of 8

2.3

1.19

0.0062

GOCC:0032991

Protein-containing complex

8 of 1391

0.66

0.48

0.0058

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF06808

Tripartite ATP-independent periplasmic transporter, DctM component

3 of 3

2.9

2.48

3.01e-05

PF04290

Tripartite ATP-independent periplasmic transporters, DctQ component

3 of 3

2.9

2.48

3.01e-05

PF03480

Bacterial extracellular solute-binding protein, family 7

3 of 3

2.9

2.48

3.01e-05

PF00289

Biotin carboxylase, N-terminal domain

2 of 5

2.5

1.16

0.0076

PF00364

Biotin-requiring enzyme

2 of 11

2.16

0.89

0.0226

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR038404

TRAP transporter solute receptor DctP superfamily

3 of 3

2.9

2.26

7.66e-05

IPR018389

TRAP transporter solute receptor DctP

3 of 3

2.9

2.26

7.66e-05

IPR010656

TRAP C4-dicarboxylate transport system permease DctM subunit

3 of 3

2.9

2.26

7.66e-05

IPR007387

TRAP transporter, small membrane protein DctQ

3 of 3

2.9

2.26

7.66e-05

IPR004681

TRAP transporter large membrane protein DctM

3 of 3

2.9

2.26

7.66e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00878

Biotin carboxylase C-terminal domain

2 of 5

2.5

1.25

0.0052

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