STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AMP23726.1Peptidase M48; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)    
Predicted Functional Partners:
AMP23727.1
CopY family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  0.968
AMP26514.1
CopY family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  0.870
AMP25750.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
  0.840
AMP21665.1
Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
  0.840
AMP22271.1
Hemerythrin; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.619
AMP23728.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
       0.503
AMP23729.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.503
grpE
Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...]
  
  
 0.493
AMP26150.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.478
dnaJ
Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...]
  
 
 0.468
Your Current Organism:
Mycobacterium simiae
NCBI taxonomy Id: 1784
Other names: ATCC 25275, CCUG 29114, CCUG 42427, CIP 104531, DSM 44165, JCM 12377, M. simiae, Mycobacterium habana
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