Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AMP24082.1Bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)    
Predicted Functional Partners:
AMP25119.1
uroporphyrin-III C-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.987
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.985
AMP24081.1
Cobalamin biosynthesis protein CbiX; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.969
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 
 0.966
AMP24297.1
uroporphyrin-III methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.955
AMP24083.1
Major facilitator transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.915
AMP24084.1
Major facilitator transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.826
AMP26255.1
Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family.
  
 
 0.825
AMP24079.1
Nitrite reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.793
AMP24078.1
Nitrite reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
  
 0.786
Your Current Organism:
Mycobacterium simiae
NCBI taxonomy Id: 1784
Other names: ATCC 25275, CCUG 29114, CCUG 42427, CIP 104531, DSM 44165, JCM 12377, M. simiae, Mycobacterium habana
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