STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AMP26233.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (179 aa)    
Predicted Functional Partners:
gyrB
Hypothetical protein; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.881
AMP26425.1
Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.810
AMP26043.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.679
AMP25556.1
Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.589
AMP21642.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.566
AMP26080.1
Trypsin; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.566
AMP23457.1
Peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.566
AMP24132.1
Trypsin; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.566
AMP25227.1
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.566
AMP26232.1
Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.490
Your Current Organism:
Mycobacterium simiae
NCBI taxonomy Id: 1784
Other names: ATCC 25275, CCUG 29114, CCUG 42427, CIP 104531, DSM 44165, JCM 12377, M. simiae, Mycobacterium habana
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.