STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AMP24509.15,10-methylene tetrahydromethanopterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (329 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
  0.900
fbiA
2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.
 
   
 0.683
AMP23339.1
NADP oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.658
fbiB
F420-0--gamma-glutamyl ligase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. In the N-terminal section; belongs to the CofE family.
 
  
 0.642
AMP23363.1
Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   
 0.633
AMP25351.1
Deazaflavin-dependent nitroreductase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   
 0.617
AMP24212.1
Monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.609
AMP23762.1
Luciferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.603
AMP21812.1
Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.596
AMP22439.1
NADP oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.596
Your Current Organism:
Mycobacterium simiae
NCBI taxonomy Id: 1784
Other names: ATCC 25275, CCUG 29114, CCUG 42427, CIP 104531, DSM 44165, JCM 12377, M. simiae, Mycobacterium habana
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