Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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[Homology]
Score
AMP24942.1Methionine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa)    
Predicted Functional Partners:
AMP22048.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.783
AMP21984.1
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
  
 0.777
AMP26385.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.765
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 
 0.726
AMP22118.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.714
AMP25087.1
GCN5 family acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.693
AMP24016.1
Lipoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.692
AMP26111.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.677
AMP24131.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.670
AMP26188.1
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.665
Your Current Organism:
Mycobacterium simiae
NCBI taxonomy Id: 1784
Other names: ATCC 25275, CCUG 29114, CCUG 42427, CIP 104531, DSM 44165, JCM 12377, M. simiae, Mycobacterium habana
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