STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AMP25011.1Nitrogen regulatory protein P-II 1; Indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; Derived by automated computational analysis using gene prediction method: Protein Homology. (112 aa)    
Predicted Functional Partners:
AMP25010.1
Ammonia channel protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 0.999
glnD
protein-PII uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.
 
 
 0.999
AMP25021.1
Ammonia channel protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 0.999
argB
Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.
    
 
 0.978
AMP23681.1
Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.893
AMP22296.1
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.892
AMP22089.1
Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.841
AMP22584.1
Regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 
 0.798
AMP25742.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 
 0.792
AMP25748.1
Tetratricopeptide repeat domain protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 
 0.792
Your Current Organism:
Mycobacterium simiae
NCBI taxonomy Id: 1784
Other names: ATCC 25275, CCUG 29114, CCUG 42427, CIP 104531, DSM 44165, JCM 12377, M. simiae, Mycobacterium habana
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