STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AMP25475.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)    
Predicted Functional Partners:
ftsH
Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
   
 0.995
AMP25474.1
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.969
AMP23618.1
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
0.921
AMP26417.1
Zinc protease; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase M16 family.
  
 0.904
AMP22511.1
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.901
AMP25476.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.817
AMP21984.1
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
   
 0.786
AMP25473.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.776
AMP21647.1
Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.763
arc
ATPase AAA; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
   
 
 0.758
Your Current Organism:
Mycobacterium simiae
NCBI taxonomy Id: 1784
Other names: ATCC 25275, CCUG 29114, CCUG 42427, CIP 104531, DSM 44165, JCM 12377, M. simiae, Mycobacterium habana
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.