Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
glnEGlutamine-synthetase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transducti [...] (1010 aa)    
Predicted Functional Partners:
glnA2
Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family.
  
  
 0.909
glnA1_2
Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.794
glnA1_1
Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.793
glnD
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
 
   
 0.791
tap
Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.763
ORW92533.1
Thioesterase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.751
rbpA
Hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. Belongs to the RNA polymerase-binding protein RbpA family.
  
     0.703
rnd
3'-5' exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.682
ORW97598.1
Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   
 0.681
glnB
Transcriptional regulator; Indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 
 0.667
Your Current Organism:
Mycolicibacter terrae
NCBI taxonomy Id: 1788
Other names: ATCC 15755, CCUG 27847, CIP 104321, DSM 43227, JCM 12143, LMG 10394, LMG:10394, M. terrae, Mycobacterium terrae
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