Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ORW88336.1DNA topoisomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)    
Predicted Functional Partners:
uvrD2
ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.901
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.796
rnhB
Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
   
 
 0.761
sbcD
DNA repair exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.751
dnaN
DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
    
 
 0.735
recQ
Recombinase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.735
prfB
Peptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
    
   0.704
ORW88692.1
ATP-dependent DNA ligase; Catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA and has been shown to have polymerase activity; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.621
rnd
3'-5' exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.602
ORW88335.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.592
Your Current Organism:
Mycolicibacter terrae
NCBI taxonomy Id: 1788
Other names: ATCC 15755, CCUG 27847, CIP 104321, DSM 43227, JCM 12143, LMG 10394, LMG:10394, M. terrae, Mycobacterium terrae
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