| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ORW93639.1 | ORW93641.1 | AWC28_16350 | AWC28_16360 | Alpha/beta hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphomethylpyrimidine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.855 |
| ORW93639.1 | pamO_1 | AWC28_16350 | AWC28_16345 | Alpha/beta hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.723 |
| ORW93639.1 | thiD | AWC28_16350 | AWC28_16355 | Alpha/beta hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.943 |
| ORW93641.1 | ORW93639.1 | AWC28_16360 | AWC28_16350 | Phosphomethylpyrimidine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Alpha/beta hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.855 |
| ORW93641.1 | moeB1 | AWC28_16360 | AWC28_19270 | Phosphomethylpyrimidine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Molybdopterin biosynthesis-like protein MoeZ; The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; Derived by automated computational analysis using gene prediction method: Protein [...] | 0.873 |
| ORW93641.1 | pamO_1 | AWC28_16360 | AWC28_16345 | Phosphomethylpyrimidine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.736 |
| ORW93641.1 | ribG | AWC28_16360 | AWC28_09985 | Phosphomethylpyrimidine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.516 |
| ORW93641.1 | tenA | AWC28_16360 | AWC28_20120 | Phosphomethylpyrimidine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thiaminase II; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4- amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2- methylpyrimidine (HMP); Belongs to the TenA family. | 0.548 |
| ORW93641.1 | thiD | AWC28_16360 | AWC28_16355 | Phosphomethylpyrimidine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.994 |
| ORW93641.1 | thiE | AWC28_16360 | AWC28_16295 | Phosphomethylpyrimidine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.908 |
| ORW93641.1 | thiG | AWC28_16360 | AWC28_16310 | Phosphomethylpyrimidine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. | 0.980 |
| ORW93641.1 | thiS | AWC28_16360 | AWC28_16305 | Phosphomethylpyrimidine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thiamine biosynthesis protein ThiS; With ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.879 |
| moeB1 | ORW93641.1 | AWC28_19270 | AWC28_16360 | Molybdopterin biosynthesis-like protein MoeZ; The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; Derived by automated computational analysis using gene prediction method: Protein [...] | Phosphomethylpyrimidine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.873 |
| moeB1 | rhlE1 | AWC28_19270 | AWC28_14495 | Molybdopterin biosynthesis-like protein MoeZ; The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; Derived by automated computational analysis using gene prediction method: Protein [...] | DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.491 |
| moeB1 | ribG | AWC28_19270 | AWC28_09985 | Molybdopterin biosynthesis-like protein MoeZ; The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; Derived by automated computational analysis using gene prediction method: Protein [...] | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.544 |
| moeB1 | tenA | AWC28_19270 | AWC28_20120 | Molybdopterin biosynthesis-like protein MoeZ; The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; Derived by automated computational analysis using gene prediction method: Protein [...] | Thiaminase II; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4- amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2- methylpyrimidine (HMP); Belongs to the TenA family. | 0.627 |
| moeB1 | thiD | AWC28_19270 | AWC28_16355 | Molybdopterin biosynthesis-like protein MoeZ; The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; Derived by automated computational analysis using gene prediction method: Protein [...] | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.863 |
| moeB1 | thiE | AWC28_19270 | AWC28_16295 | Molybdopterin biosynthesis-like protein MoeZ; The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; Derived by automated computational analysis using gene prediction method: Protein [...] | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.887 |
| moeB1 | thiG | AWC28_19270 | AWC28_16310 | Molybdopterin biosynthesis-like protein MoeZ; The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; Derived by automated computational analysis using gene prediction method: Protein [...] | Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. | 0.985 |
| moeB1 | thiS | AWC28_19270 | AWC28_16305 | Molybdopterin biosynthesis-like protein MoeZ; The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; Derived by automated computational analysis using gene prediction method: Protein [...] | Thiamine biosynthesis protein ThiS; With ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.928 |
