rnhB protein (Mycolicibacter terrae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

rnhB

Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (239 aa)

Predicted Functional Partners:

lepB

0.952

coaE

0.901

polA_1

0.900

dnaN

0.860

uvrD2

0.855

ORW89581.1

0.855

ORW92444.1

0.838

rplS

0.837

recQ

0.786

eryA

0.769

Your Current Organism:

Mycolicibacter terrae

NCBI taxonomy Id: 1788
Other names: ATCC 15755, CCUG 27847, CIP 104321, DSM 43227, JCM 12143, LMG 10394, LMG:10394, M. terrae, Mycobacterium terrae

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ORW89581.1	lepB	AWC28_20670	AWC28_20660	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	S26 family signal peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S26 family.	0.855
ORW89581.1	rnhB	AWC28_20670	AWC28_20665	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.	0.855
ORW89581.1	rplS	AWC28_20670	AWC28_20655	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.	0.649
ORW92444.1	dnaN	AWC28_00915	AWC28_00205	Acid phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.560
ORW92444.1	eryA	AWC28_00915	AWC28_16745	Acid phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Beta-ketoacyl synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.487
ORW92444.1	polA_1	AWC28_00915	AWC28_04140	Acid phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.860
ORW92444.1	recQ	AWC28_00915	AWC28_02210	Acid phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Recombinase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.444
ORW92444.1	rnhB	AWC28_00915	AWC28_20665	Acid phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.	0.838
ORW92444.1	uvrD2	AWC28_00915	AWC28_19315	Acid phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.627
coaE	eryA	AWC28_04125	AWC28_16745	dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.	Beta-ketoacyl synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.714
coaE	polA_1	AWC28_04125	AWC28_04140	dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.815
coaE	rnhB	AWC28_04125	AWC28_20665	dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.	Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.	0.901
coaE	uvrD2	AWC28_04125	AWC28_19315	dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.	ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.456
dnaN	ORW92444.1	AWC28_00205	AWC28_00915	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	Acid phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.560
dnaN	eryA	AWC28_00205	AWC28_16745	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	Beta-ketoacyl synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.603
dnaN	polA_1	AWC28_00205	AWC28_04140	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.991
dnaN	recQ	AWC28_00205	AWC28_02210	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	Recombinase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.796
dnaN	rnhB	AWC28_00205	AWC28_20665	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.	0.860
dnaN	uvrD2	AWC28_00205	AWC28_19315	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.983
eryA	ORW92444.1	AWC28_16745	AWC28_00915	Beta-ketoacyl synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acid phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.487