AFZ05326.1 protein (Oscillatoria nigroviridis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

AFZ05326.1

TPR repeat-containing protein; COGs: COG3914 O-linked N-acetylglucosamine transferase SPINDLY family; KEGG: npu:Npun_F0677 TPR repeat-containing protein; SPTR: Putative uncharacterized protein. (744 aa)

Predicted Functional Partners:

AFZ08646.1

0.902

AFZ05059.1

0.864

AFZ09180.1

0.835

AFZ10020.1

0.786

AFZ08649.1

0.761

AFZ10399.1

0.682

AFZ08264.1

0.623

AFZ09428.1

0.589

AFZ09800.1

0.563

AFZ07734.1

0.555

Your Current Organism:

Oscillatoria nigroviridis

NCBI taxonomy Id: 179408
Other names: O. nigro-viridis PCC 7112, Oscillatoria nigro-viridis PCC 7112, Oscillatoria sp. PCC 7112

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFZ05059.1	AFZ05326.1	Osc7112_0451	Osc7112_0738	Tetratricopeptide TPR_1 repeat-containing protein; PFAM: Tetratricopeptide repeat; InterPro IPR001440:IPR019734; KEGG: ter:Tery_3751 tetratricopeptide TPR_2; PFAM: Tetratricopeptide TPR-1; SPTR: Tetratricopeptide TPR_2.	TPR repeat-containing protein; COGs: COG3914 O-linked N-acetylglucosamine transferase SPINDLY family; KEGG: npu:Npun_F0677 TPR repeat-containing protein; SPTR: Putative uncharacterized protein.	0.864
AFZ05326.1	AFZ05059.1	Osc7112_0738	Osc7112_0451	TPR repeat-containing protein; COGs: COG3914 O-linked N-acetylglucosamine transferase SPINDLY family; KEGG: npu:Npun_F0677 TPR repeat-containing protein; SPTR: Putative uncharacterized protein.	Tetratricopeptide TPR_1 repeat-containing protein; PFAM: Tetratricopeptide repeat; InterPro IPR001440:IPR019734; KEGG: ter:Tery_3751 tetratricopeptide TPR_2; PFAM: Tetratricopeptide TPR-1; SPTR: Tetratricopeptide TPR_2.	0.864
AFZ05326.1	AFZ07734.1	Osc7112_0738	Osc7112_3355	TPR repeat-containing protein; COGs: COG3914 O-linked N-acetylglucosamine transferase SPINDLY family; KEGG: npu:Npun_F0677 TPR repeat-containing protein; SPTR: Putative uncharacterized protein.	PFAM: Protein of unknown function (DUF3352); KEGG: ter:Tery_0595 hypothetical protein; SPTR: Putative uncharacterized protein.	0.555
AFZ05326.1	AFZ08264.1	Osc7112_0738	Osc7112_3927	TPR repeat-containing protein; COGs: COG3914 O-linked N-acetylglucosamine transferase SPINDLY family; KEGG: npu:Npun_F0677 TPR repeat-containing protein; SPTR: Putative uncharacterized protein.	Hypothetical protein; KEGG: npu:Npun_F0676 general secretion pathway protein H; SPTR: Putative uncharacterized protein.	0.623
AFZ05326.1	AFZ08646.1	Osc7112_0738	Osc7112_4336	TPR repeat-containing protein; COGs: COG3914 O-linked N-acetylglucosamine transferase SPINDLY family; KEGG: npu:Npun_F0677 TPR repeat-containing protein; SPTR: Putative uncharacterized protein.	Tetratricopeptide TPR_1 repeat-containing protein; PFAM: Tetratricopeptide repeat; COGs: COG4783 Putative Zn-dependent protease contains TPR repeats; InterPro IPR019734:IPR001440; KEGG: mar:MAE_58050 tetratricopeptide TPR_2; PFAM: Tetratricopeptide TPR-1; SMART: Tetratricopeptide repeat; SPTR: Tetratricopeptide TPR_2.	0.902
AFZ05326.1	AFZ08649.1	Osc7112_0738	Osc7112_4339	TPR repeat-containing protein; COGs: COG3914 O-linked N-acetylglucosamine transferase SPINDLY family; KEGG: npu:Npun_F0677 TPR repeat-containing protein; SPTR: Putative uncharacterized protein.	PFAM: Tetratricopeptide repeat; COGs: COG5010 Flp pilus assembly protein TadD contains TPR repeats; InterPro IPR019734:IPR001440; KEGG: mar:MAE_58050 tetratricopeptide TPR_2; PFAM: Tetratricopeptide TPR-1; SMART: Tetratricopeptide repeat; SPTR: Tetratricopeptide TPR_2.	0.761
AFZ05326.1	AFZ09180.1	Osc7112_0738	Osc7112_4912	TPR repeat-containing protein; COGs: COG3914 O-linked N-acetylglucosamine transferase SPINDLY family; KEGG: npu:Npun_F0677 TPR repeat-containing protein; SPTR: Putative uncharacterized protein.	PFAM: Tetratricopeptide repeat; COGs: COG3063 Tfp pilus assembly protein PilF; InterPro IPR001440:IPR013105:IPR019734; KEGG: ter:Tery_1492 glycosyl transferase family protein; PFAM: Tetratricopeptide TPR-1; Tetratricopeptide TPR2; SMART: Tetratricopeptide repeat; SPTR: Putative uncharacterized protein.	0.835
AFZ05326.1	AFZ09428.1	Osc7112_0738	Osc7112_5174	TPR repeat-containing protein; COGs: COG3914 O-linked N-acetylglucosamine transferase SPINDLY family; KEGG: npu:Npun_F0677 TPR repeat-containing protein; SPTR: Putative uncharacterized protein.	PFAM: Tetratricopeptide repeat; COGs: COG3063 Tfp pilus assembly protein PilF; InterPro IPR013105:IPR001440:IPR019734; KEGG: mar:MAE_03610 TPR repeat-containing protein; PFAM: Tetratricopeptide TPR-1; Tetratricopeptide TPR2; SMART: Tetratricopeptide repeat; SPTR: TPR repeat protein.	0.589
AFZ05326.1	AFZ09800.1	Osc7112_0738	Osc7112_5577	TPR repeat-containing protein; COGs: COG3914 O-linked N-acetylglucosamine transferase SPINDLY family; KEGG: npu:Npun_F0677 TPR repeat-containing protein; SPTR: Putative uncharacterized protein.	Tetratricopeptide TPR_2 repeat-containing protein; PFAM: Tetratricopeptide repeat; InterPro IPR019734:IPR001440:IPR013105; KEGG: ter:Tery_1947 tetratricopeptide TPR_2; PFAM: Tetratricopeptide TPR2; Tetratricopeptide TPR-1; SPTR: TPR repeat protein.	0.563
AFZ05326.1	AFZ10020.1	Osc7112_0738	Osc7112_5812	TPR repeat-containing protein; COGs: COG3914 O-linked N-acetylglucosamine transferase SPINDLY family; KEGG: npu:Npun_F0677 TPR repeat-containing protein; SPTR: Putative uncharacterized protein.	PFAM: Tetratricopeptide repeat; COGs: COG3063 Tfp pilus assembly protein PilF; InterPro IPR019734:IPR001440; KEGG: mar:MAE_01800 TPR repeat-containing protein; PFAM: Tetratricopeptide TPR-1; SMART: Tetratricopeptide repeat; SPTR: Tetratricopeptide repeat protein.	0.786
AFZ05326.1	AFZ10399.1	Osc7112_0738	Osc7112_6220	TPR repeat-containing protein; COGs: COG3914 O-linked N-acetylglucosamine transferase SPINDLY family; KEGG: npu:Npun_F0677 TPR repeat-containing protein; SPTR: Putative uncharacterized protein.	Tetratricopeptide TPR_2 repeat-containing protein; PFAM: Tetratricopeptide repeat; InterPro IPR019734:IPR001440:IPR013105; KEGG: pmt:PMT0296 TPR repeat-containing protein; PFAM: Tetratricopeptide TPR2; Tetratricopeptide TPR-1; SPTR: Putative uncharacterized protein.	0.682
AFZ07734.1	AFZ05326.1	Osc7112_3355	Osc7112_0738	PFAM: Protein of unknown function (DUF3352); KEGG: ter:Tery_0595 hypothetical protein; SPTR: Putative uncharacterized protein.	TPR repeat-containing protein; COGs: COG3914 O-linked N-acetylglucosamine transferase SPINDLY family; KEGG: npu:Npun_F0677 TPR repeat-containing protein; SPTR: Putative uncharacterized protein.	0.555
AFZ07734.1	AFZ08264.1	Osc7112_3355	Osc7112_3927	PFAM: Protein of unknown function (DUF3352); KEGG: ter:Tery_0595 hypothetical protein; SPTR: Putative uncharacterized protein.	Hypothetical protein; KEGG: npu:Npun_F0676 general secretion pathway protein H; SPTR: Putative uncharacterized protein.	0.514
AFZ08264.1	AFZ05326.1	Osc7112_3927	Osc7112_0738	Hypothetical protein; KEGG: npu:Npun_F0676 general secretion pathway protein H; SPTR: Putative uncharacterized protein.	TPR repeat-containing protein; COGs: COG3914 O-linked N-acetylglucosamine transferase SPINDLY family; KEGG: npu:Npun_F0677 TPR repeat-containing protein; SPTR: Putative uncharacterized protein.	0.623
AFZ08264.1	AFZ07734.1	Osc7112_3927	Osc7112_3355	Hypothetical protein; KEGG: npu:Npun_F0676 general secretion pathway protein H; SPTR: Putative uncharacterized protein.	PFAM: Protein of unknown function (DUF3352); KEGG: ter:Tery_0595 hypothetical protein; SPTR: Putative uncharacterized protein.	0.514
AFZ08646.1	AFZ05326.1	Osc7112_4336	Osc7112_0738	Tetratricopeptide TPR_1 repeat-containing protein; PFAM: Tetratricopeptide repeat; COGs: COG4783 Putative Zn-dependent protease contains TPR repeats; InterPro IPR019734:IPR001440; KEGG: mar:MAE_58050 tetratricopeptide TPR_2; PFAM: Tetratricopeptide TPR-1; SMART: Tetratricopeptide repeat; SPTR: Tetratricopeptide TPR_2.	TPR repeat-containing protein; COGs: COG3914 O-linked N-acetylglucosamine transferase SPINDLY family; KEGG: npu:Npun_F0677 TPR repeat-containing protein; SPTR: Putative uncharacterized protein.	0.902
AFZ08649.1	AFZ05326.1	Osc7112_4339	Osc7112_0738	PFAM: Tetratricopeptide repeat; COGs: COG5010 Flp pilus assembly protein TadD contains TPR repeats; InterPro IPR019734:IPR001440; KEGG: mar:MAE_58050 tetratricopeptide TPR_2; PFAM: Tetratricopeptide TPR-1; SMART: Tetratricopeptide repeat; SPTR: Tetratricopeptide TPR_2.	TPR repeat-containing protein; COGs: COG3914 O-linked N-acetylglucosamine transferase SPINDLY family; KEGG: npu:Npun_F0677 TPR repeat-containing protein; SPTR: Putative uncharacterized protein.	0.761
AFZ09180.1	AFZ05326.1	Osc7112_4912	Osc7112_0738	PFAM: Tetratricopeptide repeat; COGs: COG3063 Tfp pilus assembly protein PilF; InterPro IPR001440:IPR013105:IPR019734; KEGG: ter:Tery_1492 glycosyl transferase family protein; PFAM: Tetratricopeptide TPR-1; Tetratricopeptide TPR2; SMART: Tetratricopeptide repeat; SPTR: Putative uncharacterized protein.	TPR repeat-containing protein; COGs: COG3914 O-linked N-acetylglucosamine transferase SPINDLY family; KEGG: npu:Npun_F0677 TPR repeat-containing protein; SPTR: Putative uncharacterized protein.	0.835
AFZ09428.1	AFZ05326.1	Osc7112_5174	Osc7112_0738	PFAM: Tetratricopeptide repeat; COGs: COG3063 Tfp pilus assembly protein PilF; InterPro IPR013105:IPR001440:IPR019734; KEGG: mar:MAE_03610 TPR repeat-containing protein; PFAM: Tetratricopeptide TPR-1; Tetratricopeptide TPR2; SMART: Tetratricopeptide repeat; SPTR: TPR repeat protein.	TPR repeat-containing protein; COGs: COG3914 O-linked N-acetylglucosamine transferase SPINDLY family; KEGG: npu:Npun_F0677 TPR repeat-containing protein; SPTR: Putative uncharacterized protein.	0.589
AFZ09800.1	AFZ05326.1	Osc7112_5577	Osc7112_0738	Tetratricopeptide TPR_2 repeat-containing protein; PFAM: Tetratricopeptide repeat; InterPro IPR019734:IPR001440:IPR013105; KEGG: ter:Tery_1947 tetratricopeptide TPR_2; PFAM: Tetratricopeptide TPR2; Tetratricopeptide TPR-1; SPTR: TPR repeat protein.	TPR repeat-containing protein; COGs: COG3914 O-linked N-acetylglucosamine transferase SPINDLY family; KEGG: npu:Npun_F0677 TPR repeat-containing protein; SPTR: Putative uncharacterized protein.	0.563

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006383

Transcription by RNA polymerase III

6 of 20

2.48

4.96

1.46e-10

GO:0006384

Transcription initiation from RNA polymerase III promoter

4 of 6

2.83

3.83

7.83e-08

GO:0006351

Transcription, DNA-templated

8 of 185

1.64

2.93

2.04e-09

GO:0006352

DNA-templated transcription, initiation

5 of 54

1.97

2.8

8.23e-07

GO:0070898

RNA polymerase III preinitiation complex assembly

2 of 2

3.0

1.61

0.0012

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140223

General transcription initiation factor activity

3 of 16

2.28

1.61

0.00092

GO:0050464

Nitrate reductase (NADPH) activity

2 of 2

3.0

1.41

0.0028

GO:0000995

RNA polymerase III general transcription initiation factor activity

2 of 2

3.0

1.41

0.0028

GO:0043546

Molybdopterin cofactor binding

2 of 5

2.61

1.31

0.0041

GO:0030151

Molybdenum ion binding

2 of 11

2.26

1.14

0.0077

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0090576

RNA polymerase III transcription regulator complex

5 of 5

3.0

5.49

6.98e-11

GO:0000127

Transcription factor TFIIIC complex

3 of 3

3.0

2.96

4.07e-06

GO:0000126

Transcription factor TFIIIB complex

2 of 2

3.0

1.64

0.0011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:834

Transcription factor TFIIIC complex, and Histidine phosphatase superfamily, clade-1

4 of 5

2.91

3.77

1.14e-07

CL:1661

RNA polymerase III complex, and Transcription factor TFIIIB complex

3 of 20

2.18

1.84

0.00028

CL:13449

Oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor, and Cytochrome b5, heme-binding site

2 of 7

2.46

1.42

0.0024

CL:1481

RNA Polymerase II Pre-transcription Events, and RNA polymerase

4 of 117

1.54

1.41

0.00049

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-76066

RNA Polymerase III Transcription Initiation From Type 2 Promoter

7 of 24

2.47

6.21

1.98e-13

MAP-76061

RNA Polymerase III Transcription Initiation From Type 1 Promoter

7 of 24

2.47

6.21

1.98e-13

MAP-76046

RNA Polymerase III Transcription Initiation

7 of 24

2.47

6.21

1.98e-13

MAP-74158

RNA Polymerase III Transcription

7 of 24

2.47

6.21

1.98e-13

MAP-74160

Gene expression (Transcription)

8 of 540

1.17

1.45

9.18e-07

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03404

Mo-co oxidoreductase dimerisation domain

2 of 4

2.7

1.03

0.0135

PF00174

Oxidoreductase molybdopterin binding domain

2 of 4

2.7

1.03

0.0135

PF00970

Oxidoreductase FAD-binding domain

2 of 7

2.46

1.02

0.0135

PF00175

Oxidoreductase NAD-binding domain

2 of 15

2.13

0.82

0.0304

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036374

Oxidoreductase, molybdopterin-binding domain superfamily

2 of 4

2.7

0.79

0.0374

IPR008335

Eukaryotic molybdopterin oxidoreductase

2 of 4

2.7

0.79

0.0374

IPR005066

Moybdenum cofactor oxidoreductase, dimerisation

2 of 4

2.7

0.79

0.0374

IPR000572

Oxidoreductase, molybdopterin-binding domain

2 of 4

2.7

0.79

0.0374

IPR008333

Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain

2 of 7

2.46

0.78

0.0374

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00384

DNA binding domain with preference for A/T rich regions

2 of 11

2.26

0.9

0.0218

SM01117

Cytochrome b5-like Heme/Steroid binding domain

2 of 24

1.92

0.71

0.0452

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (30%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About