STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFZ06841.1Multi-sensor signal transduction histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Phytochrome region; His Kinase A (phosphoacceptor) domain; PAS fold; COGs: COG4251 Bacteriophytochrome (light-regulated signal transduction histidine kinase); InterPro IPR013654:IPR003018:IPR013515:IPR003594; KEGG: cyn:Cyan7425_4415 multi-sensor signal transduction histidine kinase; PFAM: PAS fold-2; GAF; Phytochrome, central region; ATPase-like, ATP-binding domain; SMART: ATPase-like, ATP-binding domain; GAF; SPTR: Putative Cyanobacterial phytochrome B. (840 aa)    
Predicted Functional Partners:
AFZ05336.1
PFAM: Response regulator receiver domain; COGs: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; KEGG: naz:Aazo_2338 GAF sensor-containing adenylate/guanylate cyclase; SPTR: Adenylate/guanylate cyclase with GAF sensor(S).
  
     0.567
AFZ09796.1
Response regulator receiver modulated GAF sensor protein; PFAM: Response regulator receiver domain; COGs: COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain; InterPro IPR001789:IPR003018; KEGG: ava:Ava_1423 response regulator receiver (CheY) and GAF domain-containing protein; PFAM: Signal transduction response regulator, receiver domain; GAF; SMART: Signal transduction response regulator, receiver domain; SPTR: Putative GAF sensor protein.
  
     0.565
AFZ06842.1
PFAM: Complex I intermediate-associated protein 30 (CIA30); NmrA-like family; COGs: COG0702 nucleoside-diphosphate-sugar epimerase; InterPro IPR001509:IPR013857; KEGG: npu:Npun_F6553 NADH:ubiquinone oxidoreductase complex I intermediate-associated protein 30; PFAM: NADH:ubiquinone oxidoreductase intermediate-associated protein 30; NAD-dependent epimerase/dehydratase; SPTR: NmrA-like.
 
     0.563
AFZ08393.1
PFAM: Response regulator receiver domain; COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterPro IPR001789; KEGG: amr:AM1_3566 response regulator; PFAM: Signal transduction response regulator, receiver domain; SMART: Signal transduction response regulator, receiver domain; SPTR: Response regulator receiver.
  
 
   0.550
AFZ08759.1
PFAM: Response regulator receiver domain; COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterPro IPR001789; KEGG: amr:AM1_3566 response regulator; PFAM: Signal transduction response regulator, receiver domain; SMART: Signal transduction response regulator, receiver domain; SPTR: Response regulator receiver.
  
 
   0.548
AFZ09607.1
PAS/PAC sensor hybrid histidine kinase; PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR003661:IPR003594:IPR001789:IPR 001610:IPR013656:IPR013655; KEGG: npu:Npun_F2908 multi-sensor hybrid histidine kinase; PFAM: Signal transduction response regulator, receiver domain; ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; PAS [...]
 
 
 
 0.528
AFZ08706.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; Hpt domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR001789:IPR001610:IPR003661:IPR 003594:IPR008207:IPR013655:IPR013767; KEGG: syp:SYNPCC7002_A1261 two-component hybrid sensor and regulator; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; PAS fold-3; Signal transduction response regulator, receiver domain [...]
  
 
 0.495
AFZ05544.1
Signal transduction histidine kinase with CheB and CheR activity; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.
 
 
 
 0.492
AFZ10416.1
PFAM: Response regulator receiver domain; COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterPro IPR001789; KEGG: ana:all2955 two-component response regulator; PFAM: Signal transduction response regulator, receiver domain; SMART: Signal transduction response regulator, receiver domain; SPTR: Response regulator receiver.
  
 
   0.483
AFZ10409.1
KaiA family protein; Component of the kaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The kaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it enhances the phosphorylation status of kaiC. In contrast, the presence of kaiB in the complex decreases the phosphorylation status of kaiC, suggesting that kaiB acts by antagonizing the interaction between kaiA and kaiC. A kaiA dimer is sufficient to enhance kaiC hexamer pho [...]
   
 
 0.480
Your Current Organism:
Oscillatoria nigroviridis
NCBI taxonomy Id: 179408
Other names: O. nigro-viridis PCC 7112, Oscillatoria nigro-viridis PCC 7112, Oscillatoria sp. PCC 7112
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.