STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
menD2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene -1-carboxylatesynthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily. (645 aa)    
Predicted Functional Partners:
AFZ09729.1
Isochorismate synthase; PFAM: chorismate binding enzyme; TIGRFAM: isochorismate synthases; COGs: COG1169 Isochorismate synthase; InterPro IPR004561:IPR015890; KEGG: ter:Tery_4072 isochorismate synthases; PFAM: Chorismate binding, C-terminal; PRIAM: Isochorismate synthase; SPTR: Isochorismate synthases; TIGRFAM: Isochorismate synthase.
 
 0.996
menH
2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC); Belongs to the AB hydrolase superfamily. MenH family.
 
 0.995
menB
1,4-Dihydroxy-2-naphthoyl-CoA synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA).
  
 0.902
menA
1,4-dihydroxy-2-naphthoate phytyltransferase; Involved in the synthesis of phylloquinone (vitamin K1). Catalyzes the transfer of a prenyl chain to 2-carboxy-1,4- naphthoquinone; Belongs to the MenA family. Type 2 subfamily.
 
   
 0.844
AFZ09723.1
o-succinylbenzoate--CoA ligase; PFAM: AMP-binding enzyme; COGs: COG0318 Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; InterPro IPR000873; KEGG: npu:Npun_R6458 O-succinylbenzoic acid--CoA ligase; PFAM: AMP-dependent synthetase/ligase; PRIAM: o-succinylbenzoate--CoA ligase; SPTR: O-succinylbenzoic acid--CoA ligase.
   
 0.809
menC
O-succinylbenzoic acid (OSB) synthetase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
 
   
 0.785
AFZ09721.1
1,4-dihydroxy-2-naphthoyl-CoA hydrolase; Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis; Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. DHNA-CoA hydrolase subfamily.
  
   
 0.556
AFZ09730.1
PFAM: Antibiotic biosynthesis monooxygenase; COGs: COG2329 Uncharacterized protein involved in biosynthesis of extracellular polysaccharides; InterPro IPR007138; KEGG: bcx:BCA_3196 YczJ; PFAM: Antibiotic biosynthesis monooxygenase; SPTR: Putative uncharacterized protein.
       0.554
Your Current Organism:
Oscillatoria nigroviridis
NCBI taxonomy Id: 179408
Other names: O. nigro-viridis PCC 7112, Oscillatoria nigro-viridis PCC 7112, Oscillatoria sp. PCC 7112
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