AFZ10364.1 protein (Oscillatoria nigroviridis)

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second shell of interactors

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Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

AFZ10364.1

KEGG: cyp:PCC8801_1291 hypothetical protein; SPTR: Putative uncharacterized protein. (190 aa)

Predicted Functional Partners:

AFZ10365.1

0.670

AFZ10366.1

0.422

Your Current Organism:

Oscillatoria nigroviridis

NCBI taxonomy Id: 179408
Other names: O. nigro-viridis PCC 7112, Oscillatoria nigro-viridis PCC 7112, Oscillatoria sp. PCC 7112

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFZ10364.1	AFZ10365.1	Osc7112_6182	Osc7112_6183	KEGG: cyp:PCC8801_1291 hypothetical protein; SPTR: Putative uncharacterized protein.	PFAM: Small integral membrane protein (DUF2273); KEGG: cyp:PCC8801_1290 hypothetical protein; SPTR: Putative uncharacterized protein.	0.670
AFZ10364.1	AFZ10366.1	Osc7112_6182	Osc7112_6184	KEGG: cyp:PCC8801_1291 hypothetical protein; SPTR: Putative uncharacterized protein.	ATPase; PFAM: NB-ARC domain; InterPro IPR011579; KEGG: ter:Tery_2292 ATPase; SPTR: Putative ATPase.	0.422
AFZ10365.1	AFZ10364.1	Osc7112_6183	Osc7112_6182	PFAM: Small integral membrane protein (DUF2273); KEGG: cyp:PCC8801_1290 hypothetical protein; SPTR: Putative uncharacterized protein.	KEGG: cyp:PCC8801_1291 hypothetical protein; SPTR: Putative uncharacterized protein.	0.670
AFZ10365.1	AFZ10366.1	Osc7112_6183	Osc7112_6184	PFAM: Small integral membrane protein (DUF2273); KEGG: cyp:PCC8801_1290 hypothetical protein; SPTR: Putative uncharacterized protein.	ATPase; PFAM: NB-ARC domain; InterPro IPR011579; KEGG: ter:Tery_2292 ATPase; SPTR: Putative ATPase.	0.479
AFZ10366.1	AFZ10364.1	Osc7112_6184	Osc7112_6182	ATPase; PFAM: NB-ARC domain; InterPro IPR011579; KEGG: ter:Tery_2292 ATPase; SPTR: Putative ATPase.	KEGG: cyp:PCC8801_1291 hypothetical protein; SPTR: Putative uncharacterized protein.	0.422
AFZ10366.1	AFZ10365.1	Osc7112_6184	Osc7112_6183	ATPase; PFAM: NB-ARC domain; InterPro IPR011579; KEGG: ter:Tery_2292 ATPase; SPTR: Putative ATPase.	PFAM: Small integral membrane protein (DUF2273); KEGG: cyp:PCC8801_1290 hypothetical protein; SPTR: Putative uncharacterized protein.	0.479

Network Stats

number of nodes:

11

number of edges:

47

average node degree:

8.55

avg. local clustering coefficient:

0.878

expected number of edges:

13

PPI enrichment p-value:

1.84e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022900

Electron transport chain

6 of 73

2.27

4.09

3.68e-09

GO:0042775

Mitochondrial ATP synthesis coupled electron transport

5 of 35

2.51

4.01

1.80e-08

GO:0032981

Mitochondrial respiratory chain complex I assembly

5 of 44

2.41

3.9

2.08e-08

GO:0045333

Cellular respiration

6 of 110

2.09

3.58

1.80e-08

GO:0019646

Aerobic electron transport chain

4 of 30

2.48

3.22

6.88e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015453

Oxidoreduction-driven active transmembrane transporter activity

7 of 38

2.62

6.78

3.66e-14

GO:0009055

Electron transfer activity

7 of 51

2.49

6.34

1.21e-13

GO:0003954

NADH dehydrogenase activity

6 of 26

2.71

6.19

1.20e-12

GO:0008137

NADH dehydrogenase (ubiquinone) activity

5 of 23

2.69

5.02

2.68e-10

GO:0016491

Oxidoreductase activity

9 of 742

1.43

2.47

3.47e-10

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005746

Mitochondrial respirasome

8 of 48

2.57

7.85

9.10e-17

GO:0098803

Respiratory chain complex

8 of 52

2.54

7.77

9.10e-17

GO:1990204

Oxidoreductase complex

8 of 75

2.38

7.02

6.30e-16

GO:0098800

Inner mitochondrial membrane protein complex

8 of 99

2.26

6.37

4.15e-15

GO:0005747

Mitochondrial respiratory chain complex I

6 of 31

2.64

6.2

7.54e-13

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:33201259

(2021) Mitochondrial respiratory supercomplexes in mammalian cells: structural versus functional role.

3 of 21

2.51

1.62

0.0010

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3506

NADH dehydrogenase complex, and Respiratory chain complex III

8 of 38

2.67

8.16

5.40e-17

CL:3510

NADH dehydrogenase complex

5 of 25

2.65

4.96

3.07e-10

CL:3566

Mitochondrial respiratory chain complex III, and Peptidase M16, N-terminal

2 of 5

2.95

1.61

0.0012

CL:3545

Mitochondrial electron transport, NADH to ubiquinone

2 of 6

2.87

1.56

0.0015

CL:4828

Tryptophan catabolism

2 of 11

2.61

1.31

0.0040

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

amj00190

Oxidative phosphorylation

8 of 90

2.3

6.68

1.26e-15

amj01100

Metabolic pathways

10 of 1264

1.25

1.96

1.14e-10

amj00380

Tryptophan metabolism

2 of 40

2.05

1.09

0.0085

amj04260

Cardiac muscle contraction

2 of 62

1.86

0.94

0.0149

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-611105

Respiratory electron transport

8 of 88

2.31

6.37

1.05e-14

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

8 of 110

2.21

5.94

2.89e-14

MAP-6799198

Complex I biogenesis

6 of 44

2.49

5.5

9.59e-12

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

8 of 162

2.04

5.07

3.83e-13

MAP-1430728

Metabolism

11 of 2271

1.04

1.35

1.37e-09

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

10 of 11323

0.3

0.25

0.0241

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070469

Respirasome

7 of 47

2.52

6.48

8.05e-14

GOCC:0005747

Mitochondrial respiratory chain complex I

4 of 19

2.67

3.65

1.44e-07

GOCC:0005743

Mitochondrial inner membrane

5 of 168

1.82

2.52

1.56e-06

GOCC:0032117

Horsetail-astral microtubule array

2 of 3

3.17

2.12

0.00015

GOCC:1902495

Transmembrane transporter complex

4 of 178

1.7

1.78

9.25e-05

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0830

Ubiquinone

6 of 45

2.48

5.51

8.61e-12

KW-0679

Respiratory chain

3 of 9

2.87

3.07

2.36e-06

KW-0496

Mitochondrion

3 of 116

1.76

1.37

0.0014

KW-0999

Mitochondrion inner membrane

2 of 38

2.07

1.08

0.0091

KW-0349

Heme

2 of 73

1.79

0.81

0.0268

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