STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uvrA_2Daunorubicin resistance protein DrrC; Derived by automated computational analysis using gene prediction method: Protein Homology. (787 aa)    
Predicted Functional Partners:
uvrB
Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
 
 0.997
mfd
Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.
   
 
 0.924
uvrC
Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
 
 0.871
KLO54849.1
Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.835
KLO52667.1
Gluconolaconase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.783
rhaS_4
AraC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.783
yhhW_1
Quercetin 2,3-dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pirin family.
       0.782
polC
Hypothetical protein; Contains 3'-5'exonuclease domain; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.684
pcrA_1
ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.646
pcrA_2
ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.622
Your Current Organism:
Mycolicibacterium senegalense
NCBI taxonomy Id: 1796
Other names: ATCC 35796, CCUG 21001, CIP 104941, DSM 43656, JCM 15467, Mycobacterium farcinogenes subsp. senegalense, Mycobacterium senegalense, NCTC 10956, strain IEMVT 378
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