node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KLO50615.1 | egtE | ABW05_02940 | ABW05_18335 | Fe-S cluster assembly protein SufB; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pyridoxal-5'-phosphate-dependent protein; Probably catalyzes the conversion of hercynylcysteine sulfoxide to ergothioneine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily. | 0.861 |
KLO50615.1 | nifU | ABW05_02940 | ABW05_02920 | Fe-S cluster assembly protein SufB; Derived by automated computational analysis using gene prediction method: Protein Homology. | Nitrogen fixation protein NifU; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.994 |
KLO50615.1 | sufC | ABW05_02940 | ABW05_02930 | Fe-S cluster assembly protein SufB; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cysteine desulfurase; Part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
KLO50615.1 | sufD | ABW05_02940 | ABW05_02935 | Fe-S cluster assembly protein SufB; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.941 |
KLO50615.1 | ygdK | ABW05_02940 | ABW05_08395 | Fe-S cluster assembly protein SufB; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cysteine desufuration protein SufE; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.500 |
KLO51886.1 | egtE | ABW05_10475 | ABW05_18335 | Endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pyridoxal-5'-phosphate-dependent protein; Probably catalyzes the conversion of hercynylcysteine sulfoxide to ergothioneine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily. | 0.903 |
egtB | egtC_2 | ABW05_18320 | ABW05_18325 | iron(II)-dependent oxidoreductase EgtB; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family. | Amidohydrolase; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. | 0.999 |
egtB | egtD | ABW05_18320 | ABW05_18330 | iron(II)-dependent oxidoreductase EgtB; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family. | histidyl-tRNA synthetase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. | 0.999 |
egtB | egtE | ABW05_18320 | ABW05_18335 | iron(II)-dependent oxidoreductase EgtB; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family. | Pyridoxal-5'-phosphate-dependent protein; Probably catalyzes the conversion of hercynylcysteine sulfoxide to ergothioneine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily. | 0.978 |
egtB | gshA | ABW05_18320 | ABW05_18315 | iron(II)-dependent oxidoreductase EgtB; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family. | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. | 0.998 |
egtC_2 | egtB | ABW05_18325 | ABW05_18320 | Amidohydrolase; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. | iron(II)-dependent oxidoreductase EgtB; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family. | 0.999 |
egtC_2 | egtD | ABW05_18325 | ABW05_18330 | Amidohydrolase; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. | histidyl-tRNA synthetase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. | 0.996 |
egtC_2 | egtE | ABW05_18325 | ABW05_18335 | Amidohydrolase; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. | Pyridoxal-5'-phosphate-dependent protein; Probably catalyzes the conversion of hercynylcysteine sulfoxide to ergothioneine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily. | 0.994 |
egtC_2 | gshA | ABW05_18325 | ABW05_18315 | Amidohydrolase; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. | 0.986 |
egtD | egtB | ABW05_18330 | ABW05_18320 | histidyl-tRNA synthetase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. | iron(II)-dependent oxidoreductase EgtB; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family. | 0.999 |
egtD | egtC_2 | ABW05_18330 | ABW05_18325 | histidyl-tRNA synthetase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. | Amidohydrolase; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. | 0.996 |
egtD | egtE | ABW05_18330 | ABW05_18335 | histidyl-tRNA synthetase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. | Pyridoxal-5'-phosphate-dependent protein; Probably catalyzes the conversion of hercynylcysteine sulfoxide to ergothioneine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily. | 0.988 |
egtD | gshA | ABW05_18330 | ABW05_18315 | histidyl-tRNA synthetase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. | 0.989 |
egtE | KLO50615.1 | ABW05_18335 | ABW05_02940 | Pyridoxal-5'-phosphate-dependent protein; Probably catalyzes the conversion of hercynylcysteine sulfoxide to ergothioneine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily. | Fe-S cluster assembly protein SufB; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.861 |
egtE | KLO51886.1 | ABW05_18335 | ABW05_10475 | Pyridoxal-5'-phosphate-dependent protein; Probably catalyzes the conversion of hercynylcysteine sulfoxide to ergothioneine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily. | Endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.903 |