STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rskA_1Anti-sigma K factor; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK. ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the regu [...] (235 aa)    
Predicted Functional Partners:
sigK_1
RNA polymerase sigma factor SigK; Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. bovis this protein has been shown to be involved in expression of antigenic proteins; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily.
 
 
 0.999
KLO53709.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.865
KLO53710.1
Amine oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.842
KLO53707.1
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.841
cfa_1
Cyclopropane-fatty-acyl-phospholipid synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.835
fgd_1
Luciferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.669
hchA_1
Chaperone protein HchA; Hsp31 stabilizes early unfolding protein intermediates under severe heat stress; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.566
KLO52895.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.506
eccE1_2
Type VII secretion protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.488
KLO54449.1
Aminoglycoside resistance protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.478
Your Current Organism:
Mycolicibacterium senegalense
NCBI taxonomy Id: 1796
Other names: ATCC 35796, CCUG 21001, CIP 104941, DSM 43656, JCM 15467, Mycobacterium farcinogenes subsp. senegalense, Mycobacterium senegalense, NCTC 10956, strain IEMVT 378
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.