Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RMCT_0138Hypothetical protein. (198 aa)    
Predicted Functional Partners:
topA
DNA topoisomerase I topA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA [...]
       0.709
EspR
Helix-turn-helix protein.
  
     0.683
Cfp6
Low molecular weight protein antigen 6 cfp6.
  
     0.680
RMCT_1569
Putative uncharacterized protein.
  
     0.660
RMCT_0704
Peptidoglycan-binding LysM.
  
     0.595
RMCT_1781
Hypothetical protein.
  
     0.582
RMCT_4652
Rieske (2Fe-2S) domain-containing protein.
  
     0.566
RMCT_0712
Transmembrane protein.
  
     0.565
RMCT_0190
Hypothetical protein.
  
     0.557
RMCT_1133
Hypothetical protein.
  
     0.554
Your Current Organism:
Mycolicibacterium thermoresistibile
NCBI taxonomy Id: 1797
Other names: ATCC 19527, CCUG 28008, CCUG 41353, CIP 105390, DSM 44167, JCM 6362, M. thermoresistibile, Mycobacterium thermoresistibile, NCTC 10409
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