Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DegQTrypsin-like serine protease with C-terminal PDZ domain. (415 aa)    
Predicted Functional Partners:
MoaB
Pterin-4-alpha-carbinolamine dehydratase moaB2.
  
  
 0.935
MprA
Two component response transcriptional regulatory protein MprA.
  
  
 0.723
RMCT_3495
Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family.
  
  
 0.688
htpX
Heat shock protein HtpX; Belongs to the peptidase M48B family.
  
  
 0.679
htpX-2
Peptidase M48 Ste24p; Belongs to the peptidase M48B family.
  
  
 0.679
IdeR_2
Iron-dependent repressor and activator ideR.
  
    0.670
glpK
Glycerol kinase GlpK; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.
   
 0.668
arc
ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
   
 0.659
MprB
Two component system sensor kinase mprB.
 
  
 0.642
Mec
Mov34/MPN/PAD-1 family protein.
  
 0.634
Your Current Organism:
Mycolicibacterium thermoresistibile
NCBI taxonomy Id: 1797
Other names: ATCC 19527, CCUG 28008, CCUG 41353, CIP 105390, DSM 44167, JCM 6362, M. thermoresistibile, Mycobacterium thermoresistibile, NCTC 10409
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