Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MhpD2-keto-4-pentenoate hydratase. (261 aa)    
Predicted Functional Partners:
BphI
4-hydroxy-2-ketovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
 
 
 0.998
BphJ
Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
 
  
 0.991
HsaD_2
Alpha/beta hydrolase fold protein.
 
 
 0.940
GarL
hpcH/HpaI aldolase; Belongs to the HpcH/HpaI aldolase family.
  
 0.816
HpcH
HpcH/HpaI aldolase; Belongs to the HpcH/HpaI aldolase family.
  
 0.805
KsdD
3-ketosteroid-delta-1-dehydrogenase.
     
 0.704
mhpB
2,3-dihydroxyphenylpropionate/2, 3-dihydroxicinnamic acid 1,2-dioxygenase; Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6- ketononatrienedioate, respectively; Belongs to the LigB/MhpB extradiol dioxygenase family.
 
  
 0.690
RMCT_1947
Dehydrogenase.
  
    0.578
HsaC
Biphenyl-2,3-diol-1,2-dioxygenase bphC.
 
  
 0.576
HsaD_3
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase bphD.
 
  
 0.576
Your Current Organism:
Mycolicibacterium thermoresistibile
NCBI taxonomy Id: 1797
Other names: ATCC 19527, CCUG 28008, CCUG 41353, CIP 105390, DSM 44167, JCM 6362, M. thermoresistibile, Mycobacterium thermoresistibile, NCTC 10409
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